1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-
- CAS No.
- 1111637-68-3
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-
- Synonyms
- 5-Bromo-3-fluoro-7-azaindole;5-broMo-3-fluoro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-;(R)-N-(3-(6-((4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
- CBNumber
- CB42603896
- Molecular Formula
- C7H4BrFN2
- Formula Weight
- 215.02
- MOL File
- 1111637-68-3.mol
1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Property
- Density
- 1.861±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.46±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 145034
- Product name
- 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $737
- Updated
- 2021/12/16
- Product number
- 145034
- Product name
- 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $1179
- Updated
- 2021/12/16
- Product number
- CD11351371
- Product name
- 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- A464996
- Product name
- 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $106
- Updated
- 2021/12/16
- Product number
- CM149593
- Product name
- 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%+
- Packaging
- 100mg
- Price
- $173
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Chemical Properties,Usage,Production
Synthesis
183208-35-7
1111637-68-3
General procedure for the synthesis of 5-bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridines from 5-bromo-7-azaindoles: first, 3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid (67) was prepared. Compound 65 (4 g, 20 mmol) was dissolved in a mixed solution of acetonitrile (500 mL) and acetic acid (100 mL), followed by the addition of Select-Fluor (10 g, 30 mmol). The reaction mixture was heated and reacted at 80°C overnight. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether/ethyl acetate, 5:1, v/v) to confirm complete consumption of compound 65. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel fast column chromatography (eluent was petroleum ether/ethyl acetate, 10:1, v/v) to afford compound 66 (0.64 g, 13% yield) as an off-white solid.1H NMR (400 MHz, CDCl3): δ 9.434 (brs, 1H), 8.311-8.280 (m , 1H), 8.056-8.023 (m, 1H), 7.191 (s, 1H), 7.086-7.053 (m, 1H).
References
[1] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 51
1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Suppliers
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