4-cyano-3-nitrobenzoic acid
- Product Name
- 4-cyano-3-nitrobenzoic acid
- CAS No.
- 153775-42-9
- Chemical Name
- 4-cyano-3-nitrobenzoic acid
- Synonyms
- 4-cyano-3-nitrobenzoic acid;Benzoic acid, 4-cyano-3-nitro-
- CBNumber
- CB42604914
- Molecular Formula
- C8H4N2O4
- Formula Weight
- 192.13
- MOL File
- 153775-42-9.mol
4-cyano-3-nitrobenzoic acid Property
- Melting point:
- 205-206 °C
- Boiling point:
- 438.1±40.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.91±0.10(Predicted)
- color
- Pale Yellow to Light Yellow
N-Bromosuccinimide Price
- Product number
- B419865
- Product name
- 4-Cyano-3-nitrobenzoicAcid
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC33254
- Product name
- 4-Cyano-3-nitrobenzoic acid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- X8067
- Product name
- 4-Cyano-3-nitrobenzoicacid
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- FC33254
- Product name
- 4-Cyano-3-nitrobenzoic acid
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC33254
- Product name
- 4-Cyano-3-nitrobenzoic acid
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
4-cyano-3-nitrobenzoic acid Chemical Properties,Usage,Production
Synthesis
26830-95-5
153775-42-9
Example 17: Alternative preparation of 4-cyano-3-nitrobenzoic acid Periodic acid (492 g, 2.17 mol) was dissolved in acetonitrile (7.71 L) under an inert atmosphere with vigorous stirring. after 15 min, chromium (VI) oxide (25 g, 0.25 mol) and 4-methyl-2-nitrobenzonitrile (100 g, 0.62 mol) were added sequentially. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was decanted and the supernatant was filtered. The filtrate was concentrated and the residue was partitioned between 1 M aqueous sodium carbonate solution and dichloromethane. The precipitate was separated by filtration to give 4-cyano-3-nitrobenzoic acid (150 g). The filtrate was extracted twice with dichloromethane and then acidified with aqueous 4N hydrochloric acid to pH 1. The acidified filtrate was extracted three times with dichloromethane. The organic extracts were combined, dried over sodium sulfate and concentrated. The residue was partitioned between 1 M aqueous sodium carbonate and dichloromethane. The precipitate was separated by filtration to give 4-cyano-3-nitrobenzoic acid (26.67 g). Total yield: 150 g + 26.67 g = 176.67 g; 74.5% yield.
References
[1] Patent: WO2008/74427, 2008, A1. Location in patent: Page/Page column 52
[2] Patent: WO2012/59442, 2012, A2. Location in patent: Page/Page column 88-89
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 24, p. 11250 - 11260
4-cyano-3-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-cyano-3-nitrobenzoic acid Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 4-cyano-3-nitrobenzoic acid manufacturers
- Product
- 4-cyano-3-nitrobenzoic acid 153775-42-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10000kgs
- Release date
- 2025-05-08