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Nutlin-3b

Product Name
Nutlin-3b
CAS No.
675576-97-3
Chemical Name
Nutlin-3b
Synonyms
CS-986;Nutlin-3b;9-trioxaundecane;11-Bis(tosyloxy)-3;NUTLIN-3B;NUTLIN 3B;Nutlin-3b USP/EP/BP;(+)-NUTLIN-3;NUTLIN 3B;Nutlin-3b - Nutlin-3, (+)-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CBNumber
CB42624268
Molecular Formula
C30H30Cl2N4O4
Formula Weight
581.49
MOL File
675576-97-3.mol
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Nutlin-3b Property

Density 
1.36
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form 
crystalline solid
pka
14.35±0.20(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
5mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
10mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
25mg
Price
$536
Updated
2024/03/01
TRC
Product number
N925530
Product name
Nutlin3b
Packaging
10mg
Price
$250
Updated
2021/12/16
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Nutlin-3b Chemical Properties,Usage,Production

Description

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.

Uses

Nutlin 3b is a small molecule MDM2 antagonist.

Definition

ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

References

[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7.

Nutlin-3b Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nutlin-3b manufacturers

Career Henan Chemical Co
Product
Nutlin-3b 675576-97-3
Price
US $1.00/g
Min. Order
200KG
Purity
99%
Supply Ability
2tons
Release date
2019-12-19

675576-97-3, Nutlin-3bRelated Search:

NUTLIN-3 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Imatinib mesylate Tozasertib Nutlin-3 Nutlin 3a ABT 263

  • Nutlin-3b
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
  • 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b
  • NUTLIN-3B;NUTLIN 3B
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid
  • CS-986
  • 4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
  • Nutlin-3b - Nutlin-3, (+)-
  • (+)-NUTLIN-3;NUTLIN 3B
  • Nutlin-3b USP/EP/BP
  • 11-Bis(tosyloxy)-3
  • 9-trioxaundecane
  • 675576-97-3
  • 677576-97-3
  • Inhibitors