NUTLIN-3

Product Name: NUTLIN-3
CAS No.: 548472-68-0
Chemical Name: NUTLIN-3
Synonyms: CS-390;NUTLIN-3;(?)-NUTLIN-3;Nutlin-3, >=98%;NUTLIN3;NUTLIN 3;Nutlin-3 ((±NUTLIN-3 (Free base);MDM2 Antagonist, Nutlin-3, Racemic;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
CBNumber: CB5101900
Molecular Formula: C30H30Cl2N4O4
Formula Weight: 581.49
MOL File: 548472-68-0.mol

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NUTLIN-3 Property

Melting point:: >132oC (dec.)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 20 mg/mL, soluble
pka: 14.35±0.20(Predicted)
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey: BDUHCSBCVGXTJM-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N6287
Product name: Nutlin-3
Purity: ≥98% (HPLC), powder
Packaging: 1mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: 444143
Product name: MDM2 Antagonist, Nutlin-3, Racemic
Packaging: 1mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 10004372
Product name: (±)-Nutlin-3
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10004372
Product name: (±)-Nutlin-3
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: N6287
Product name: Nutlin-3
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $442
Updated: 2024/03/01

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NUTLIN-3 Chemical Properties,Usage,Production

Description

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.

Uses

(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.

Definition

ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.

Biochem/physiol Actions

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

storage

Store at -20°C

References

1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859

NUTLIN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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NUTLIN-3 Suppliers

China 120 India 1 Switzerland 3 The Netherlands 1 United Kingdom 2 United States 23 Global 150

Shanghai Bank Pharma Limited

Tel: 021-2221346380 021-54220652 17701603001
Fax: QQ:2221346380
Email: bankpharma@163.com
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
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Chembest Research Laboratories Limited

Tel: 021-20908456
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Email: sales@BioChemBest.com
Country: China
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Goodee Pharma Co., Ltd.

Tel: 0512-62956210
Email: yongyan@goodeepharma.com
Country: China
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Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 021-50430803 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
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ProdList: 9352
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Email: info@chemexpress.com
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
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Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
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View Lastest Price from NUTLIN-3 manufacturers

Career Henan Chemical Co

Product: Nutlin (3) 548472-68-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

548472-68-0, NUTLIN-3Related Search:

Nutlin-3b Nutlin 3a ZM 447439 Imatinib mesylate Sunitinib Malate Cantharidin 2-Ethoxybenzamidine hydrochloride 1-(2-METHOXYBENZYLAMINO)-2-(4-CHLOROPHENYL)ETHANE NUTLIN-3 2,4-DIMETHOXY-BENZAMIDINE PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE meso-1,2-Bis(4-chlorophenyl)ethylenediamine CHEMBRDG-BB 5543528 CHEMBRDG-BB 5570316 2,4-DIMETHOXY-BENZAMIDINE HCL 2-(4 5-DIHYDRO-1H-IMIDAZOL-2-YL)PHENOL

(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE

NUTLIN-3

2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-

4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-

4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one

Nutlin-3, >=98%

NUTLIN-3 (Free base)

4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony

MDM2 Antagonist, Nutlin-3, Racemic

MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

(?)-NUTLIN-3

Nutlin-3 ((&plusmn

NUTLIN3;NUTLIN 3

CS-390

4-(cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

548472-68-0

C30H30Cl2N4O4

Inhibitors