ChemicalBook > CAS DataBase List > NUTLIN-3

NUTLIN-3

Product Name
NUTLIN-3
CAS No.
548472-68-0
Chemical Name
NUTLIN-3
Synonyms
CS-390;NUTLIN-3;(?)-NUTLIN-3;Nutlin-3, >=98%;NUTLIN3;NUTLIN 3;Nutlin-3 ((±NUTLIN-3 (Free base);MDM2 Antagonist, Nutlin-3, Racemic;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
CBNumber
CB5101900
Molecular Formula
C30H30Cl2N4O4
Formula Weight
581.49
MOL File
548472-68-0.mol
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NUTLIN-3 Property

Melting point:
>132oC (dec.)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 20 mg/mL, soluble
pka
14.35±0.20(Predicted)
form 
solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey
BDUHCSBCVGXTJM-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N6287
Product name
Nutlin-3
Purity
≥98% (HPLC), powder
Packaging
1mg
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
444143
Product name
MDM2 Antagonist, Nutlin-3, Racemic
Packaging
1mg
Price
$144
Updated
2024/03/01
Cayman Chemical
Product number
10004372
Product name
(±)-Nutlin-3
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10004372
Product name
(±)-Nutlin-3
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
N6287
Product name
Nutlin-3
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$442
Updated
2024/03/01
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NUTLIN-3 Chemical Properties,Usage,Production

Description

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.

Uses

(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.

Definition

ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.

Biochem/physiol Actions

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

storage

Store at -20°C

References

1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859

NUTLIN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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NUTLIN-3 Suppliers

China 121 India 1 Switzerland 3 The Netherlands 1 United Kingdom 2 United States 23 Global 151
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View Lastest Price from NUTLIN-3 manufacturers

Career Henan Chemical Co
Product
Nutlin (3) 548472-68-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

548472-68-0, NUTLIN-3Related Search:

Nutlin-3b Nutlin 3a ZM 447439 Imatinib mesylate Sunitinib Malate Cantharidin 2-Ethoxybenzamidine hydrochloride 1-(2-METHOXYBENZYLAMINO)-2-(4-CHLOROPHENYL)ETHANE NUTLIN-3 2,4-DIMETHOXY-BENZAMIDINE PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE meso-1,2-Bis(4-chlorophenyl)ethylenediamine CHEMBRDG-BB 5543528 CHEMBRDG-BB 5570316 2,4-DIMETHOXY-BENZAMIDINE HCL 2-(4 5-DIHYDRO-1H-IMIDAZOL-2-YL)PHENOL

  • (+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE
  • NUTLIN-3
  • 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
  • 4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
  • Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
  • 4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one
  • Nutlin-3, >=98%
  • NUTLIN-3 (Free base)
  • 4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
  • MDM2 Antagonist, Nutlin-3, Racemic
  • MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
  • (?)-NUTLIN-3
  • Nutlin-3 ((&plusmn
  • NUTLIN3;NUTLIN 3
  • CS-390
  • 4-(cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
  • 548472-68-0
  • C30H30Cl2N4O4
  • Inhibitors