NUTLIN-3
- Product Name
- NUTLIN-3
- CAS No.
- 548472-68-0
- Chemical Name
- NUTLIN-3
- Synonyms
- CS-390;NUTLIN-3;(?)-NUTLIN-3;Nutlin-3, >=98%;NUTLIN3;NUTLIN 3;Nutlin-3 ((±NUTLIN-3 (Free base);MDM2 Antagonist, Nutlin-3, Racemic;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
- CBNumber
- CB5101900
- Molecular Formula
- C30H30Cl2N4O4
- Formula Weight
- 581.49
- MOL File
- 548472-68-0.mol
NUTLIN-3 Property
- Melting point:
- >132oC (dec.)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 20 mg/mL, soluble
- pka
- 14.35±0.20(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChIKey
- BDUHCSBCVGXTJM-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N6287
- Product name
- Nutlin-3
- Purity
- ≥98% (HPLC), powder
- Packaging
- 1mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 444143
- Product name
- MDM2 Antagonist, Nutlin-3, Racemic
- Packaging
- 1mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 10004372
- Product name
- (±)-Nutlin-3
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 10004372
- Product name
- (±)-Nutlin-3
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- N6287
- Product name
- Nutlin-3
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $442
- Updated
- 2024/03/01
NUTLIN-3 Chemical Properties,Usage,Production
Description
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.
Uses
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
Definition
ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.
Biochem/physiol Actions
Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.
storage
Store at -20°C
References
1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859
NUTLIN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
NUTLIN-3 Suppliers
View Lastest Price from NUTLIN-3 manufacturers
- Product
- Nutlin (3) 548472-68-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10