ChemicalBook > CAS DataBase List > Nutlin-3b

Nutlin-3b

Product Name
Nutlin-3b
CAS No.
675576-97-3
Chemical Name
Nutlin-3b
Synonyms
CS-986;Nutlin-3b;9-trioxaundecane;11-Bis(tosyloxy)-3;NUTLIN-3B;NUTLIN 3B;Nutlin-3b USP/EP/BP;(+)-NUTLIN-3;NUTLIN 3B;Nutlin-3b - Nutlin-3, (+)-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CBNumber
CB42624268
Molecular Formula
C30H30Cl2N4O4
Formula Weight
581.49
MOL File
675576-97-3.mol
More
Less

Nutlin-3b Property

Density 
1.36
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form 
crystalline solid
pka
14.35±0.20(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
5mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
10mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
25mg
Price
$536
Updated
2024/03/01
TRC
Product number
N925530
Product name
Nutlin3b
Packaging
10mg
Price
$250
Updated
2021/12/16
More
Less

Nutlin-3b Chemical Properties,Usage,Production

Description

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.

Uses

Nutlin 3b is a small molecule MDM2 antagonist.

Definition

ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

References

[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7.

Nutlin-3b Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Nutlin-3b Suppliers

China 76 France 1 The Netherlands 1 United States 15 Global 93
Chengdu Senior Pharma Technology Co.Ltd.
Tel
+86-0838-2319818 +86-15982001943
Email
seniorpharma@163.com
Country
China
ProdList
411
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
Country
China
ProdList
977
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Wuhan HengHeDa Pharm Co., Ltd.
Tel
27-27-84888682 18086046872
Fax
027-84888682
Email
hhdpharm@hotmail.com
Country
China
ProdList
117
Advantage
55
More
Less

View Lastest Price from Nutlin-3b manufacturers

Career Henan Chemical Co
Product
Nutlin-3b 675576-97-3
Price
US $1.00/g
Min. Order
200KG
Purity
99%
Supply Ability
2tons
Release date
2019-12-19

675576-97-3, Nutlin-3bRelated Search:

NUTLIN-3 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Imatinib mesylate Tozasertib Nutlin-3 Nutlin 3a ABT 263

  • Nutlin-3b
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
  • 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b
  • NUTLIN-3B;NUTLIN 3B
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid
  • CS-986
  • 4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
  • Nutlin-3b - Nutlin-3, (+)-
  • (+)-NUTLIN-3;NUTLIN 3B
  • Nutlin-3b USP/EP/BP
  • 11-Bis(tosyloxy)-3
  • 9-trioxaundecane
  • 675576-97-3
  • 677576-97-3
  • Inhibitors