ChemicalBook > CAS DataBase List > AM095

AM095

Product Name
AM095
CAS No.
1228690-36-5
Chemical Name
AM095
Synonyms
CS-1624;AM 095 ，S6633;AM095 (free acid);AM-095 (free base);AM 095 (parent compound);AM095 free acid, 10 mM in DMSO;AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID;[4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid;2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid;[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-
CBNumber
CB42624905
Molecular Formula
C27H24N2O5
Formula Weight
456.49
MOL File
1228690-36-5.mol
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AM095 Property

Boiling point:
641.9±55.0 °C(Predicted)
Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic
form 
Powder
pka
4.21±0.10(Predicted)
color 
White to off-white
InChIKey
LNDDRUPAICPXIN-GOSISDBHSA-N
SMILES
C1(C2=CC=C(C3ON=C(C)C=3NC(O[C@@H](C3=CC=CC=C3)C)=O)C=C2)=CC=C(CC(O)=O)C=C1
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22141
Product name
AM095
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
22141
Product name
AM095
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
22141
Product name
AM095
Purity
≥98%
Packaging
25mg
Price
$356
Updated
2024/03/01
ApexBio Technology
Product number
A3167
Product name
AM-095freebase
Packaging
50mg
Price
$488
Updated
2021/12/16
ChemScene
Product number
CS-1129
Product name
AM095freeacid
Purity
99.28%
Packaging
50mg
Price
$540
Updated
2021/12/16
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AM095 Chemical Properties,Usage,Production

Uses

AM095 (free acid) is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.

Biological Activity

am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].

in vitro

am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].

in vivo

am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].

target

LPA1 receptor

References

[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.

AM095 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM095 Suppliers

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View Lastest Price from AM095 manufacturers

Career Henan Chemical Co
Product
AM095 1228690-36-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 491
Release date
2019-09-01

1228690-36-5, AM095Related Search:

N,N-DIETHYLBENZAMIDE Adenosine 2-Methylindole Octadecyl methacrylate

  • AM-095 (free base)
  • AM095 (free acid)
  • [4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid
  • AM 095 (parent compound)
  • 2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid
  • AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID
  • CS-1624
  • [1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-
  • AM 095,Inhibitor,AM095 free acid,AM-095 free acid,inhibit,AM095,Lysophospholipid Receptor,AM-095,LPL Receptor
  • (R)-2-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid
  • AM095 free acid, 10 mM in DMSO
  • AM 095 ，S6633
  • 1228690-36-5
  • 228690-36-5