AM095
- Product Name
- AM095
- CAS No.
- 1228690-36-5
- Chemical Name
- AM095
- Synonyms
- CS-1624;AM095 (free acid);AM-095 (free base);AM 095 (parent compound);AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID;[4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid;2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid;[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-;(R)-2-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid;AM 095,Inhibitor,AM095 free acid,AM-095 free acid,inhibit,AM095,Lysophospholipid Receptor,AM-095,LPL Receptor
- CBNumber
- CB42624905
- Molecular Formula
- C27H24N2O5
- Formula Weight
- 456.49
- MOL File
- 1228690-36-5.mol
AM095 Property
- Boiling point:
- 641.9±55.0 °C(Predicted)
- Density
- 1.278±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic
- form
- Powder
- pka
- 4.21±0.10(Predicted)
- color
- White to off-white
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 22141
- Product name
- AM095
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 22141
- Product name
- AM095
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 22141
- Product name
- AM095
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- A3167
- Product name
- AM-095freebase
- Packaging
- 5mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- BISN0022
- Product name
- AM095FreeAcid
- Purity
- 98%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2021/12/16
AM095 Chemical Properties,Usage,Production
Biological Activity
am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].
in vitro
am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].
in vivo
am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].
target
LPA1 receptor
References
[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.
AM095 Preparation Products And Raw materials
Raw materials
Preparation Products
AM095 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from AM095 manufacturers
- Product
- AM095 1228690-36-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 491
- Release date
- 2019-09-01