Omadacycline

ChemicalBook > CAS DataBase List > Omadacycline

Product Name: Omadacycline
CAS No.: 389139-89-3
Chemical Name: Omadacycline
Synonyms: OMadacycline;AMadacycline;PTK-796;PTK 0796;Omadacycline-D9;Omadacycline (PTK 0796;Amadacycline，Omadacycline，PTK 0796;OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE;(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
CBNumber: CB42627315
Molecular Formula: C29H40N4O7
Formula Weight: 556.65
MOL File: 389139-89-3.mol

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Omadacycline Property

Boiling point:: 837.6±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:1.0(Max Conc. mg/mL);1.8(Max Conc. mM)
form: A crystalline solid
pka: 4.50±1.00(Predicted)
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: O633020
Product name: Omadacycline
Packaging: 25mg
Price: $1050
Updated: 2021/12/16

ApexBio Technology

Product number: A3171
Product name: Amadacycline
Packaging: 50mg
Price: $1178
Updated: 2021/12/16

ApexBio Technology

Product number: A3171
Product name: Amadacycline
Packaging: 200mg
Price: $2674
Updated: 2021/12/16

ApexBio Technology

Product number: A3171
Product name: Amadacycline
Packaging: 5mg
Price: $339
Updated: 2021/12/16

ApexBio Technology

Product number: A3171
Product name: Amadacycline
Packaging: 10mg
Price: $437
Updated: 2021/12/16

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Omadacycline Chemical Properties,Usage,Production

Description

Omadacycline, the drug that US FDA approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It is not susceptible to common tetracycline-resistancemechanisms, and has demonstrated efficacy against a broad spectrum of pathogens including resistant isolates, which are increasing in prevalence and complexity.

Uses

Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).

Definition

ChEBI: Omadacycline is a member of tetracyclines.

Pharmacology

Omadacycline has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections.The in vitro activity of Omadacycline against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 g/ml against Bacteroides spp, 0.5 g/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica,1 g/ml against Peptostreptococcus spp, and 16 g/ml against Clostridium perfringens.

Side effects

OMadacycline may cause serious adverse reactions including hypersensitivity reactions, tooth discoloration,Clostridioides difficile-associated diarrhea, and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.Common adverse reactions include nausea, vomiting, infusion site reactions, alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl transferase increased, hypertension, headache, diarrhea, insomnia, and constipation.Mild to moderate nausea and vomiting were the most frequent treatment-emergent adverse events in omadacycline (111 [30%] of 368 and 62 [17%] of 368, respectively) groups.

Omadacycline Preparation Products And Raw materials

Raw materials

Preparation Products

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389139-89-3, OmadacyclineRelated Search:

Minocycline hydrochloride Fosfomycin Oxytetracycline Linezolid Tetracycline

AMadacycline

OMadacycline

PTK 0796

PTK-796

OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-

Omadacycline-D9

Amadacycline，Omadacycline，PTK 0796

Omadacycline (PTK 0796

spectrum,antibacterial,pathogens,Omadacycline,synthesis,Inhibitor,urinary,community-acquired,PTK-0796,skin-structure,anaerobic,acute,protein,pneumonia,tetracycline,inhibit,skin,Gram-negative,atypical,Antibiotic,Gram-positive,tract,PTK0796,broad,Bacterial,infections,agent

(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

389139-89-3

C29H40N4O7