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Omadacycline

Product Name
Omadacycline
CAS No.
389139-89-3
Chemical Name
Omadacycline
Synonyms
OMadacycline;AMadacycline;PTK-796;PTK 0796;Omadacycline-D9;Omadacycline (PTK 0796;Amadacycline,Omadacycline,PTK 0796;OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE;(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
CBNumber
CB42627315
Molecular Formula
C29H40N4O7
Formula Weight
556.65
MOL File
389139-89-3.mol
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Omadacycline Property

Boiling point:
837.6±65.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:1.0(Max Conc. mg/mL);1.8(Max Conc. mM)
form 
A crystalline solid
pka
4.50±1.00(Predicted)
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
O633020
Product name
Omadacycline
Packaging
25mg
Price
$1050
Updated
2021/12/16
ApexBio Technology
Product number
A3171
Product name
Amadacycline
Packaging
50mg
Price
$1178
Updated
2021/12/16
ApexBio Technology
Product number
A3171
Product name
Amadacycline
Packaging
200mg
Price
$2674
Updated
2021/12/16
ApexBio Technology
Product number
A3171
Product name
Amadacycline
Packaging
5mg
Price
$339
Updated
2021/12/16
ApexBio Technology
Product number
A3171
Product name
Amadacycline
Packaging
10mg
Price
$437
Updated
2021/12/16
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Omadacycline Chemical Properties,Usage,Production

Description

Omadacycline, the drug that US FDA approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It is not susceptible to common tetracycline-resistancemechanisms, and has demonstrated efficacy against a broad spectrum of pathogens including resistant isolates, which are increasing in prevalence and complexity.

Uses

Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).

Definition

ChEBI: Omadacycline is a member of tetracyclines.

Pharmacology

Omadacycline has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections.The in vitro activity of Omadacycline against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 g/ml against Bacteroides spp, 0.5 g/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica,1 g/ml against Peptostreptococcus spp, and 16 g/ml against Clostridium perfringens.

Side effects

OMadacycline may cause serious adverse reactions including hypersensitivity reactions, tooth discoloration,Clostridioides difficile-associated diarrhea, and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.Common adverse reactions include nausea, vomiting, infusion site reactions, alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl transferase increased, hypertension, headache, diarrhea, insomnia, and constipation.Mild to moderate nausea and vomiting were the most frequent treatment-emergent adverse events in omadacycline (111 [30%] of 368 and 62 [17%] of 368, respectively) groups.

Omadacycline Preparation Products And Raw materials

Raw materials

Preparation Products

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Omadacycline Suppliers

389139-89-3, OmadacyclineRelated Search:


  • AMadacycline
  • OMadacycline
  • PTK 0796
  • PTK-796
  • OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE
  • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
  • Omadacycline-D9
  • Amadacycline,Omadacycline,PTK 0796
  • Omadacycline (PTK 0796
  • spectrum,antibacterial,pathogens,Omadacycline,synthesis,Inhibitor,urinary,community-acquired,PTK-0796,skin-structure,anaerobic,acute,protein,pneumonia,tetracycline,inhibit,skin,Gram-negative,atypical,Antibiotic,Gram-positive,tract,PTK0796,broad,Bacterial,infections,agent
  • (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • 389139-89-3
  • C29H40N4O7