AS601245
- Product Name
- AS601245
- CAS No.
- 345987-15-7
- Chemical Name
- AS601245
- Synonyms
- CS-1619;AS601245;AS601245.TFA;JNK Inhibitor V;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245
- CBNumber
- CB42627340
- Molecular Formula
- C20H16N6S
- Formula Weight
- 372.45
- MOL File
- 345987-15-7.mol
AS601245 Property
- Boiling point:
- 635.6±65.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO
- pka
- 5.32±0.10(Predicted)
- form
- White to yellow solid.
Safety
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 420129
- Product name
- JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
- Packaging
- 5MG
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 17542
- Product name
- JNK Inhibitor V
- Purity
- ≥98% (sum of isomers)
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 17542
- Product name
- JNK Inhibitor V
- Purity
- ≥98% (sum of isomers)
- Packaging
- 5mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 17542
- Product name
- JNK Inhibitor V
- Purity
- ≥98% (sum of isomers)
- Packaging
- 10mg
- Price
- $268
- Updated
- 2024/03/01
- Product number
- 17542
- Product name
- JNK Inhibitor V
- Purity
- ≥98% (sum of isomers)
- Packaging
- 25mg
- Price
- $535
- Updated
- 2024/03/01
AS601245 Chemical Properties,Usage,Production
Uses
JNK Inhibitor V is an anti-inflammatory JNK inhibitor with neuroprotective properties. JNK Inhibitor V and Clofibrate (C586910) synergistically inhibit proliferation, induce apoptosis and differentiation via differential modulation of gene expression profile in human colon cancer cells.
Definition
ChEBI: 2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile is a member of benzothiazoles.
Biological Activity
recent evidence suggests activation of the c-jun nh2-terminal protein kinase (jnk) signal transduction pathway may play a role in ischemia-induced cell death. therefore, preventing the activation of jnk, or c-jun phosphorylation could be neuroprotective. as601245 is a c-jun nh2-terminal protein kinase inhibitor.
in vitro
as601245 demonstrated a nonspecific inhibition of the three jnk human isoforms. as601245 inhibits isolated hjnk3 in an atpcompetitive manner. selectivity of as601245 was tested against a large panel of kinases. it exhibited 10- to 20-fold selectivity over c-src, cdk2, and c-raf and more than 50- to 100-fold selectivity over a range of tyr- and ser/thr-protein kinases [1].
in vivo
as601245 administered i.p. provided significant protection against the delayed loss of hippocampal ca1 neurons in a gerbil model of transient global ischemia. this effect is mediated by jnk inhibition and thus by c-jun expression and phosphorylation. a significant neuroprotective effect of as601245 administered either by i.p. injection or as i.v. bolus followed by an i.v. infusion was also observed in rats after focal cerebral ischemia [1].
IC 50
150, 220, and 70 nm for hjnk1, hjnk2, and hjnk3, respectively
References
[1] carboni s, hiver a, szyndralewiez c, gaillard p, gotteland jp, vitte pa. as601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-jun nh2-terminal protein kinase inhibitor with neuroprotective properties. j pharmacol exp ther. 2004 jul;310(1):25-32. epub 2004 feb 26.
AS601245 Preparation Products And Raw materials
Raw materials
Preparation Products
AS601245 Suppliers
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View Lastest Price from AS601245 manufacturers
- Product
- 2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile 345987-15-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09