AS601245

Product Name: AS601245
CAS No.: 345987-15-7
Chemical Name: AS601245
Synonyms: CS-1619;AS601245;AS601245.TFA;JNK Inhibitor V;AS601245, JNK inhibitor;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245
CBNumber: CB42627340
Molecular Formula: C20H16N6S
Formula Weight: 372.45
MOL File: 345987-15-7.mol

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AS601245 Property

Boiling point:: 635.6±65.0 °C(Predicted)
Density: 1.366±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO
pka: 5.32±0.10(Predicted)
form: White to yellow solid.
color: Light yellow to yellow

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Safety

HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420129
Product name: JNK Inhibitor V - CAS 345987-15-7 - Calbiochem
Packaging: 5MG
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 17542
Product name: JNK Inhibitor V
Purity: ≥98% (sum of isomers)
Packaging: 1mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 17542
Product name: JNK Inhibitor V
Purity: ≥98% (sum of isomers)
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Cayman Chemical

Product number: 17542
Product name: JNK Inhibitor V
Purity: ≥98% (sum of isomers)
Packaging: 10mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 17542
Product name: JNK Inhibitor V
Purity: ≥98% (sum of isomers)
Packaging: 25mg
Price: $535
Updated: 2024/03/01

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AS601245 Chemical Properties,Usage,Production

Uses

JNK Inhibitor V is an anti-inflammatory JNK inhibitor with neuroprotective properties. JNK Inhibitor V and Clofibrate (C586910) synergistically inhibit proliferation, induce apoptosis and differentiation via differential modulation of gene expression profile in human colon cancer cells.

Definition

ChEBI: 2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile is a member of benzothiazoles.

Biological Activity

recent evidence suggests activation of the c-jun nh2-terminal protein kinase (jnk) signal transduction pathway may play a role in ischemia-induced cell death. therefore, preventing the activation of jnk, or c-jun phosphorylation could be neuroprotective. as601245 is a c-jun nh2-terminal protein kinase inhibitor.

in vitro

as601245 demonstrated a nonspecific inhibition of the three jnk human isoforms. as601245 inhibits isolated hjnk3 in an atpcompetitive manner. selectivity of as601245 was tested against a large panel of kinases. it exhibited 10- to 20-fold selectivity over c-src, cdk2, and c-raf and more than 50- to 100-fold selectivity over a range of tyr- and ser/thr-protein kinases [1].

in vivo

as601245 administered i.p. provided significant protection against the delayed loss of hippocampal ca1 neurons in a gerbil model of transient global ischemia. this effect is mediated by jnk inhibition and thus by c-jun expression and phosphorylation. a significant neuroprotective effect of as601245 administered either by i.p. injection or as i.v. bolus followed by an i.v. infusion was also observed in rats after focal cerebral ischemia [1].

IC 50

150, 220, and 70 nm for hjnk1, hjnk2, and hjnk3, respectively

References

[1] carboni s, hiver a, szyndralewiez c, gaillard p, gotteland jp, vitte pa. as601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-jun nh2-terminal protein kinase inhibitor with neuroprotective properties. j pharmacol exp ther. 2004 jul;310(1):25-32. epub 2004 feb 26.

AS601245 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS601245 Suppliers

China 51 United States 13 Global 64

Target molecule Corp.

Tel: 857-239-0968
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Musechem

Tel: +1-800-259-7612
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TargetMol Chemicals Inc.

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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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Aladdin Scientific

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ApexBio Technology

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BOC Sciences

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Abcam

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Cayman Chemical Company

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United States Biological

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MedChemExpress

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Santa Cruz Biotechnology, Inc.

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View Lastest Price from AS601245 manufacturers

Career Henan Chemical Co

Product: 2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile 345987-15-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

345987-15-7, AS601245Related Search:

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2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile

AS601245

AS601245.TFA

JNK Inhibitor V

alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile

CS-1619

2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-

2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile

colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245

AS601245, JNK inhibitor

345987-15-7

Inhibitors