AZ-505

ChemicalBook > CAS DataBase List > AZ-505

Product Name: AZ-505
CAS No.: 1035227-44-1
Chemical Name: AZ-505
Synonyms: AZ-505;AZ-505 2TFA salt;AZ-505;AZ505;AZ 505;AZ505 (ditrifluoroacetate);N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide bis(2,2,2-trifluoroacetate);N-Cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide 2,2,2-trifluoroacetate (1:2)
CBNumber: CB42627355
Molecular Formula: C31H39Cl2F3N4O6
Formula Weight: 691.57
MOL File: 1035227-44-1.mol

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AZ-505 Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥119.8 mg/mL in DMSO; ≥7.3 mg/mL in EtOH with ultrasonic
form: Powder
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A808203
Product name: AZ505ditrifluoroacetate
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

TRC

Product number: A808203
Product name: AZ505ditrifluoroacetate
Packaging: 5mg
Price: $415
Updated: 2021/12/16

Apolloscientific

Product number: BISN0120
Product name: AZ505 ditrifluoroacetate
Packaging: 1mg
Price: $102
Updated: 2021/12/16

ApexBio Technology

Product number: B1256
Product name: AZ505ditrifluoroacetate
Packaging: 2mg
Price: $214
Updated: 2021/12/16

Apolloscientific

Product number: BISN0120
Product name: AZ505 ditrifluoroacetate
Packaging: 5mg
Price: $277
Updated: 2021/12/16

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AZ-505 Chemical Properties,Usage,Production

Uses

AZ505 is a potent inhibitor of SMYD2, which plays an important role in epigenetic signalling. Inhibiition of SMYD2 also functions as an activator of the tumor suppressor proteins.

Biological Activity

az505 is a potent set and mynd domain-containing 2 protein (smyd2) inhibitor that selectively inhibits the enzymatic activity of smyd2 (ic50: 0.12 μm) over a variety of other protein lysine methyltransferases (ic50 > 83.3 μμ), including smyd3, dot1l, ezh2, glp, g9a and set7/9 [1].az505 contains three distinct moieties: the benzooxazinone group which interacts with the lysine-binding channel of smyd2; the cyclohexyl group which interacts with the core set and i-set domains of smyd2; and the dichlorophenethyl group which extends across the peptide binding groove of smyd2 [1].the x-ray crystallographic analysis has revealed that az505 binds into the peptide binding groove of smyd2 competing with the peptide substrates [1].

AZ-505 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ-505 Suppliers

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1035227-44-1, AZ-505Related Search:

Deionized water VINYL PROPIONATE (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride N,N'-DICYCLOHEXYLUREA Cyclohexanone

AZ-505;AZ505;AZ 505

AZ-505

AZ505 (ditrifluoroacetate)

N-Cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide 2,2,2-trifluoroacetate (1:2)

AZ-505 2TFA salt

N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide bis(2,2,2-trifluoroacetate)

1035227-44-1

C33H40Cl2F6N4O8

C29H38Cl2N4O42C2HF3O2