AZ-505

ChemicalBook > CAS DataBase List > AZ-505

Product Name: AZ-505
CAS No.: 1035227-44-1
Chemical Name: AZ-505
Synonyms: AZ-505;AZ-505 2TFA salt;AZ-505;AZ505;AZ 505;AZ505 (ditrifluoroacetate);N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide bis(2,2,2-trifluoroacetate);N-Cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide 2,2,2-trifluoroacetate (1:2)
CBNumber: CB42627355
Molecular Formula: C31H39Cl2F3N4O6
Formula Weight: 691.57
MOL File: 1035227-44-1.mol

Less

AZ-505 Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥119.8 mg/mL in DMSO; ≥7.3 mg/mL in EtOH with ultrasonic
form: Powder

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

TRC

Product number: A808203
Product name: AZ505ditrifluoroacetate
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

TRC

Product number: A808203
Product name: AZ505ditrifluoroacetate
Packaging: 5mg
Price: $415
Updated: 2021/12/16

Apolloscientific

Product number: BISN0120
Product name: AZ505 ditrifluoroacetate
Packaging: 10mg
Price: $432
Updated: 2021/12/16

ChemScene

Product number: CS-1734
Product name: AZ505ditrifluoroacetate
Purity: 99.99%
Packaging: 50mg
Price: $1188
Updated: 2021/12/16

ApexBio Technology

Product number: B1256
Product name: AZ505ditrifluoroacetate
Packaging: 25mg
Price: $1335
Updated: 2021/12/16

Less

AZ-505 Chemical Properties,Usage,Production

Uses

AZ505 is a potent inhibitor of SMYD2, which plays an important role in epigenetic signalling. Inhibiition of SMYD2 also functions as an activator of the tumor suppressor proteins.

Biological Activity

az505 is a potent set and mynd domain-containing 2 protein (smyd2) inhibitor that selectively inhibits the enzymatic activity of smyd2 (ic50: 0.12 μm) over a variety of other protein lysine methyltransferases (ic50 > 83.3 μμ), including smyd3, dot1l, ezh2, glp, g9a and set7/9 [1].az505 contains three distinct moieties: the benzooxazinone group which interacts with the lysine-binding channel of smyd2; the cyclohexyl group which interacts with the core set and i-set domains of smyd2; and the dichlorophenethyl group which extends across the peptide binding groove of smyd2 [1].the x-ray crystallographic analysis has revealed that az505 binds into the peptide binding groove of smyd2 competing with the peptide substrates [1].

AZ-505 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

AZ-505 Suppliers

China 40 India 1 United States 11 Global 52

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3244
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1991
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9763
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44843
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7977
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 63720
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6713
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9957
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 15001810326
Email: guojianing@jskchem.com
Country: China
ProdList: 49242
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29989
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5019
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.com
Country: China
ProdList: 24246
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49739
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6652
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6805
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6107
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6039
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6164
Advantage: 58

Wuhan Kehaojia Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 2248475041@qq.com
Country: CHINA
ProdList: 2650
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6322
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6921
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6530
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6617
Advantage: 58

1035227-44-1, AZ-505Related Search:

Deionized water VINYL PROPIONATE (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride N,N'-DICYCLOHEXYLUREA Cyclohexanone

AZ-505;AZ505;AZ 505

AZ-505

AZ505 (ditrifluoroacetate)

N-Cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide 2,2,2-trifluoroacetate (1:2)

AZ-505 2TFA salt

N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide bis(2,2,2-trifluoroacetate)

1035227-44-1

C33H40Cl2F6N4O8

C29H38Cl2N4O42C2HF3O2