AZD7545

ChemicalBook > CAS DataBase List > AZD7545

Product Name: AZD7545
CAS No.: 252017-04-2
Chemical Name: AZD7545
Synonyms: CS-1842;AZD7545;AZD4575;AZD-7547;AZD 7547;AZD7547;AZD7545/AZD-7545;PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545;(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%
CBNumber: CB42627360
Molecular Formula: C19H18ClF3N2O5S
Formula Weight: 478.87
MOL File: 252017-04-2.mol

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AZD7545 Property

Boiling point:: 683.1±55.0 °C(Predicted)
Density: 1.473±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≥21.85 mg/mL in DMSO; insoluble in H2O; ≥15.63 mg/mL in EtOH with ultrasonic
form: solid
pka: 10.39±0.29(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33639
Product name: Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545 - CAS 252017-04-2 - Calbiochem
Purity: Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545, CAS 252017-04-2, is a potent, selective, reversible inhibitor of PDHK2 (IC?? = 6.4 nM). Inhibits PDHK1 at higher levels (IC?? = 36.8 nM).
Packaging: 5MG
Price: $196
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 25mg
Price: $632
Updated: 2024/03/01

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AZD7545 Chemical Properties,Usage,Production

Description

AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC₅₀ value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC₅₀s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC₅₀ = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats. It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts.

Definition

ChEBI: AZD7545 is a sulfone that is benzene substituted by [4-(dimethylcarbamoyl)phenyl]sulfonyl, chloro and [(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino groups at positions 1, 3 and 4, respectively. It is a potent and non-ATP-competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2) with IC50 of 6.4 nM and exhibits glucose-lowering activity. Also inhibits PDHK1 at higher levels (IC50 = 36.8 nM). It has a role as a hypoglycemic agent and an EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor. It is a member of benzamides, a sulfone, a tertiary alcohol, a tertiary carboxamide, a secondary carboxamide, a member of monochlorobenzenes and an organofluorine compound.

target

PDHK2

References

[1] morrell j a, orme j, butlin r j, et al. azd7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. biochemical society transactions, 2003, 31(6): 1168-1170.
[2] mayers r m, butlin r j, kilgour e, et al. azd7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (pdhk2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) zucker rats. biochemical society transactions, 2003, 31(6): 1165-1167.

AZD7545 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AZD7545 manufacturers

Career Henan Chemical Co

Product: AZD7545 252017-04-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

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PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545

252017-04-2

Inhibitors

API