AZD7545

ChemicalBook > CAS DataBase List > AZD7545

Product Name: AZD7545
CAS No.: 252017-04-2
Chemical Name: AZD7545
Synonyms: CS-1842;AZD7545;AZD4575;AZD-7547;AZD 7547;AZD7547;AZD7545/AZD-7545;PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545;(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%
CBNumber: CB42627360
Molecular Formula: C19H18ClF3N2O5S
Formula Weight: 478.87
MOL File: 252017-04-2.mol

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AZD7545 Property

Boiling point:: 683.1±55.0 °C(Predicted)
Density: 1.473±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≥21.85 mg/mL in DMSO; insoluble in H2O; ≥15.63 mg/mL in EtOH with ultrasonic
form: solid
pka: 10.39±0.29(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33639
Product name: Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545 - CAS 252017-04-2 - Calbiochem
Purity: Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545, CAS 252017-04-2, is a potent, selective, reversible inhibitor of PDHK2 (IC?? = 6.4 nM). Inhibits PDHK1 at higher levels (IC?? = 36.8 nM).
Packaging: 5MG
Price: $196
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 19282
Product name: AZD 7545
Purity: ≥98%
Packaging: 25mg
Price: $632
Updated: 2024/03/01

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AZD7545 Chemical Properties,Usage,Production

Description

AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC₅₀ value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC₅₀s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC₅₀ = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats. It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts.

Definition

ChEBI: AZD7545 is a sulfone that is benzene substituted by [4-(dimethylcarbamoyl)phenyl]sulfonyl, chloro and [(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino groups at positions 1, 3 and 4, respectively. It is a potent and non-ATP-competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2) with IC50 of 6.4 nM and exhibits glucose-lowering activity. Also inhibits PDHK1 at higher levels (IC50 = 36.8 nM). It has a role as a hypoglycemic agent and an EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor. It is a member of benzamides, a sulfone, a tertiary alcohol, a tertiary carboxamide, a secondary carboxamide, a member of monochlorobenzenes and an organofluorine compound.

target

PDHK2

References

[1] morrell j a, orme j, butlin r j, et al. azd7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. biochemical society transactions, 2003, 31(6): 1168-1170.
[2] mayers r m, butlin r j, kilgour e, et al. azd7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (pdhk2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) zucker rats. biochemical society transactions, 2003, 31(6): 1165-1167.

AZD7545 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AZD7545 manufacturers

Career Henan Chemical Co

Product: AZD7545 252017-04-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

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(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%

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4-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethylbenzamide

(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide

AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide

Benzamide, 4-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-

PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545

252017-04-2

Inhibitors

API