OSU-03012

Product Name: OSU-03012
CAS No.: 742112-33-0
Chemical Name: OSU-03012
Synonyms: AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;PDK1 inhibitor AR-12;N/AAR-12; OSU03012; OSU 03012;Osu-03012|||Osu 03012|||AR-12
CBNumber: CB22501006
Molecular Formula: C26H19F3N4O
Formula Weight: 460.45
MOL File: 742112-33-0.mol

More

Less

OSU-03012 Property

storage temp.: Store at -20°C
solubility: ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
color: White to off-white
CAS DataBase Reference: 742112-33-0

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 10mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 100mg
Price: $789
Updated: 2024/03/01

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 50mg
Price: $502
Updated: 2024/03/01

Tocris

Product number: 5682
Product name: OSU03012
Purity: ≥98%(HPLC)
Packaging: 50
Price: $648
Updated: 2021/12/16

More

Less

OSU-03012 Chemical Properties,Usage,Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC₅₀ value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

storage

Store at -20°C

References

[1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
[2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.

OSU-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

OSU-03012 Suppliers

China 107 India 1 United Kingdom 2 United States 19 Global 129

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Fax: +86-25-52131256
Email: 799750417@qq.com
Country: China
ProdList: 8878
Advantage: 55

More

Less

View Lastest Price from OSU-03012 manufacturers

Career Henan Chemical Co

Product: OSU-03012 742112-33-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

742112-33-0, OSU-03012Related Search:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Amino-3-bromo-6-chloropyrazine 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER L-Alanyl-L-Glutamine impurity 25 2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile 1H-Imidazole-4-carboxylicacid,2-amino-,ethylester(9CI) Sildenafil citrate BX-912 Axitinib Dasatinib BX-795 BEZ235 (NVP-BEZ235, Dactolisib)

OSU-03012, >=98%

OSU-03012 (AR-12)

AR-12

2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide

2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012

N/AAR-12

OSU-03012

2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide

OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012

CS-1848

N/AAR-12; OSU03012; OSU 03012

Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-

OSU-03012 USP/EP/BP

Osu-03012|||Osu 03012|||AR-12

PDK1 inhibitor AR-12

742112-33-0

C26H19F3N4O

Inhibitors

Inhibitor of phosphoinositide-dependent kinase-1.

Akt

mTOR

PI3K