ChemicalBook > CAS DataBase List > N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

Product Name
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
CAS No.
702675-74-9
Chemical Name
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Synonyms
BX 795;CS-544;BX795, >97%;BX795/BX-795;BX 795, >=98%;BX-795 ，S1274;BX-795 hydrochloride;BX795, 10 mM in DMSO;BX-795; BX 795; BX795.;BX-795 - CAS 702675-74-9 - Calbiochem
CBNumber
CB42484697
Molecular Formula
C23H26IN7O2S
Formula Weight
591.47
MOL File
702675-74-9.mol
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N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Property

Melting point:
>163°C (dec.)
Density 
1.644
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
pka
12.57±0.70(Predicted)
color 
white to light brown
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
VAVXGGRQQJZYBL-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0694
Product name
BX-795 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$107.35
Updated
2025/07/31
Sigma-Aldrich
Product number
204001
Product name
BX-795
Packaging
10mg
Price
$231
Updated
2025/07/31
Cayman Chemical
Product number
14932
Product name
BX-795
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
14932
Product name
BX-795
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0694
Product name
BX-795 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$305.9
Updated
2025/07/31
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N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Chemical Properties,Usage,Production

Description

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX-795 is a potent, ATP-competitive inhibitor of PDK1 in vitro (IC50 = 11 nM) and in cells (IC50 = 300 nM). At comparable concentrations, BX-795 also inhibits ERK8, MAPK-interacting kinase 2, Aurora B, Aurora C, MAP/microtubule affinity-regulating kinases 1-4, TNF receptor associated factor-associated NF-κB activator-binding kinase 1, IκB kinase ε, and additional kinases.

Uses

BX-795 hydrochloride has been used to study the effect of kinase inhibition on human endogenous retroviruses (HERVs) transcription activation.

Definition

ChEBI: N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas.

Biochem/physiol Actions

BX-795 competes for the ATP (adenosine triphosphate) binding pocket of 3-phosphoinositide-dependent kinase-1 (PDK1) with its substrate ATP. In vitro assays reveal that BX-795 might inhibit Unc-51 (serine/threonine-protein kinase)-like autophagy activating kinase (ULK1).

storage

Store at -20°C

References

[1] RICHARD I FELDMAN. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.[J]. The Journal of Biological Chemistry, 2005, 280 20: 19867-19874. DOI:10.1074/jbc.m501367200
[2] JENNY BAIN. The selectivity of protein kinase inhibitors: a further update.[J]. Biochemical Journal, 2007: 297-315. DOI:10.1042/bj20070797
[3] KRISTOPHER CLARK. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.[J]. The Journal of Biological Chemistry, 2009, 284 21: 14136-14146. DOI:10.1074/jbc.m109.000414
[4] LI-YUAN BAI . BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest[J]. European journal of pharmacology, 2015, 769: Pages 287-296. DOI:10.1016/j.ejphar.2015.11.032
[5] EUN A CHOI . A pharmacogenomic analysis using L1000CDS2 identifies BX-795 as a potential anticancer drug for primary pancreatic ductal adenocarcinoma cells[J]. Cancer letters, 2019, 465: Pages 82-93. DOI:10.1016/j.canlet.2019.08.002
[6] SARAH A SCUDERI. TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells.[J]. Oncology Research, 2021, 28 7: 779-790. DOI:10.3727/096504021x16161478258040
[7] TOLGA SUTLU. Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.[J]. Human gene therapy, 2012, 23 10: 1090-1100. DOI:10.1089/hum.2012.080
[8] DAVID S J ALLAN. Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion.[J]. Molecular Therapy. Methods & Clinical Development, 2021: 559-571. DOI:10.1016/j.omtm.2021.01.008
[9] PETER CHOCKLEY  Stephen G  Sagar L Patil. Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors[J]. Cytotherapy, 2021, 23 9: Pages 787-792. DOI:10.1016/j.jcyt.2021.04.010
[10] LINGYU LI. Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795.[J]. Journal of Translational Medicine, 2020: 363. DOI:10.1186/s12967-020-02526-2

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Suppliers

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Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
BX-795 702675-74-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99% HPLC
Supply Ability
1000kg
Release date
2022-11-09
Career Henan Chemical Co
Product
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 702675-74-9
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03
Career Henan Chemical Co
Product
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 702675-74-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

702675-74-9, N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamideRelated Search:

LY 294002 Hydrochloride NOTUMib-1 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Dequalinium chloride NORFLUOXETINE HYDROCHLORIDE Iodine solution Sotrastaurin xav-939 MK-2206 2HCl Saracatinib Panobinostat

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  • BX 795, >=98%
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  • BX-795 - CAS 702675-74-9 - Calbiochem
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  • IKK,Inhibitor,BX795,BX-795,I kappa B kinase,inhibit,IκB kinase,PDK-1,BX 795,Autophagy
  • BX795, 10 mM in DMSO
  • BX-795 ，S1274
  • 702675-74-9
  • C23H26IN7O2S
  • Inhibitors
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