ChemicalBook > CAS DataBase List > OSU-03012

OSU-03012

Product Name
OSU-03012
CAS No.
742112-33-0
Chemical Name
OSU-03012
Synonyms
AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;PDK1 inhibitor AR-12;N/AAR-12; OSU03012; OSU 03012;Osu-03012|||Osu 03012|||AR-12
CBNumber
CB22501006
Molecular Formula
C26H19F3N4O
Formula Weight
460.45
MOL File
742112-33-0.mol
More
Less

OSU-03012 Property

storage temp. 
Store at -20°C
solubility 
≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
color 
White to off-white
CAS DataBase Reference
742112-33-0
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10008005
Product name
OSU03012
Packaging
10mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
10008005
Product name
OSU03012
Packaging
100mg
Price
$789
Updated
2024/03/01
Cayman Chemical
Product number
10008005
Product name
OSU03012
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
10008005
Product name
OSU03012
Packaging
50mg
Price
$502
Updated
2024/03/01
Tocris
Product number
5682
Product name
OSU03012
Purity
≥98%(HPLC)
Packaging
50
Price
$648
Updated
2021/12/16
More
Less

OSU-03012 Chemical Properties,Usage,Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC50 value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

storage

Store at -20°C

References

[1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
[2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.

OSU-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

OSU-03012 Suppliers

China 107 India 1 United Kingdom 2 United States 19 Global 129
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from OSU-03012 manufacturers

Career Henan Chemical Co
Product
OSU-03012 742112-33-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

742112-33-0, OSU-03012Related Search:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Amino-3-bromo-6-chloropyrazine 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER L-Alanyl-L-Glutamine impurity 25 2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile 1H-Imidazole-4-carboxylicacid,2-amino-,ethylester(9CI) Sildenafil citrate BX-912 Axitinib Dasatinib BX-795 BEZ235 (NVP-BEZ235, Dactolisib)

  • OSU-03012, >=98%
  • OSU-03012 (AR-12)
  • AR-12
  • 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide
  • 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012
  • N/AAR-12
  • OSU-03012
  • 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
  • OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012
  • CS-1848
  • N/AAR-12; OSU03012; OSU 03012
  • Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-
  • OSU-03012 USP/EP/BP
  • Osu-03012|||Osu 03012|||AR-12
  • PDK1 inhibitor AR-12
  • 742112-33-0
  • C26H19F3N4O
  • Inhibitors
  • Inhibitor of phosphoinositide-dependent kinase-1.
  • Akt
  • mTOR
  • PI3K