OSU-03012

ChemicalBook > CAS DataBase List > OSU-03012

Product Name: OSU-03012
CAS No.: 742112-33-0
Chemical Name: OSU-03012
Synonyms: AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;N/AAR-12; OSU03012; OSU 03012;OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012;2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
CBNumber: CB22501006
Molecular Formula: C26H19F3N4O
Formula Weight: 460.45
MOL File: 742112-33-0.mol

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OSU-03012 Property

storage temp.: Store at -20°C
solubility: ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
CAS DataBase Reference: 742112-33-0

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 10mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 100mg
Price: $789
Updated: 2024/03/01

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10008005
Product name: OSU03012
Packaging: 50mg
Price: $502
Updated: 2024/03/01

Tocris

Product number: 5682
Product name: OSU03012
Purity: ≥98%(HPLC)
Packaging: 50
Price: $648
Updated: 2021/12/16

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OSU-03012 Chemical Properties,Usage,Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC₅₀ value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

storage

Store at -20°C

References

[1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
[2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.

OSU-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OSU-03012 manufacturers

Career Henan Chemical Co

Product: OSU-03012 742112-33-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

742112-33-0, OSU-03012Related Search:

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OSU-03012, >=98%

OSU-03012 (AR-12)

AR-12

2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide

2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012

N/AAR-12

OSU-03012

2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide

OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012

CS-1848

N/AAR-12; OSU03012; OSU 03012

Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-

OSU-03012 USP/EP/BP

742112-33-0

C26H19F3N4O

Inhibitors

Inhibitor of phosphoinositide-dependent kinase-1.

Akt

mTOR

PI3K