ST 2825
- Product Name
- ST 2825
- CAS No.
- 894787-30-5
- Chemical Name
- ST 2825
- Synonyms
- ST 2825;ST 2825;ST2825;(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;(2R,4'R,8'aR)-1-[2-[4-[[2-(2,4-Dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxospiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)-
- CBNumber
- CB42628433
- Molecular Formula
- C27H28Cl2N4O5S
- Formula Weight
- 591.51
- MOL File
- 894787-30-5.mol
ST 2825 Property
- Boiling point:
- 939.0±65.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- -10 to -25°C
- solubility
- Soluble in DMSO
- form
- solid
- pka
- 12.86±0.70(Predicted)
- color
- White to off-white
- InChIKey
- HBLHLJXFIPCEMW-ZJSFPPFMSA-N
- SMILES
- N1(C(CC2=CC=C(NC(COC3=CC=C(Cl)C=C3Cl)=O)C=C2)=O)CCC[C@]21C(=O)N1[C@@H](C(N)=O)CCS[C@]1([H])C2
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0797
- Product name
- ST2825
- Purity
- 99.86%
- Packaging
- 1mg
- Price
- $426
- Updated
- 2021/12/16
- Product number
- A3840
- Product name
- ST2825
- Packaging
- 1mg
- Price
- $520
- Updated
- 2021/12/16
- Product number
- CS-0797
- Product name
- ST2825
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $1464
- Updated
- 2021/12/16
- Product number
- orb611397
- Product name
- ST-2825
- Packaging
- 5mg
- Price
- $1470.5
- Updated
- 2021/12/16
- Product number
- orb611397
- Product name
- ST-2825
- Packaging
- 10mg
- Price
- $2223.6
- Updated
- 2021/12/16
ST 2825 Chemical Properties,Usage,Production
Uses
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity[1][2].
Biological Activity
st 2825 is a specific inhibitor of myd88 dimerization [1].st 2825 is a synthetic compound which mimics the structure of the heptapeptide in the bb-loop of the myd88-tir domain and interferes the homodimerization of myd88. st 2825 was proved to specifically inhibit the homodimerization of myd88 tir domains without affecting the homodimerization of death domains. in hek293t cells transfected with flag-myd88 and myc-myd88, st 2825 inhibited the interaction of the two myd88 by 80% at the concentration of 10 μm. this inhibition resulted in the subsequent interference of the irak1 and irak4 recruitment. besides that, administration of st 2825 significantly inhibited the il-6 production stimulated by il-1β at doses of 100 and 200 mg/kg in mice. furthermore, 8 μm st 2825 completely blocked the tlr9-induced b cell proliferation. st2825 also suppressed the generation of plasma cells induced by cpg dose-dependently [1].
in vivo
ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200 mg/kg, 5 min prior to i.p. injection with 20 μg/kg IL-1β. ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg[1].
target
MyD88
References
[1] loiarro m, capolunghi f, fantò n, et al. pivotal advance: inhibition of myd88 dimerization and recruitment of irak1 and irak4 by a novel peptidomimetic compound. journal of leukocyte biology, 2007, 82(4): 801-810.
ST 2825 Preparation Products And Raw materials
Raw materials
Preparation Products
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