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Saxagliptin hydrochloride

Product Name
Saxagliptin hydrochloride
CAS No.
709031-78-7
Chemical Name
Saxagliptin hydrochloride
Synonyms
Saxaint-S;Saxagliptin HCL salt;Saxagliptin hydrochloride;(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride;(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrochloride;2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-,monohydrochloride, (1S,3S,5S)-
CBNumber
CB42630096
Molecular Formula
C18H25N3O2.HCl
Formula Weight
351.88
MOL File
709031-78-7.mol
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Saxagliptin hydrochloride Property

Melting point:
>219°C
storage temp. 
-20°C
solubility 
Soluble in DMSO (20 mg/ml)
form 
solid
color 
White
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI
InChI=1/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H/t10?,11?,12-,13+,14+,15-,17?,18?;/s3
InChIKey
TUAZNHHHYVBVBR-PMEPUXBANA-N
SMILES
[C@@H](C12CC3CC(CC(C3)(O)C1)C2)(N)C(N1[C@@H](C[C@@H]2C[C@H]12)C#N)=O.Cl |&1:0,15,17,19,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H335May cause respiratory irritation

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23697
Product name
Saxagliptin (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
23697
Product name
Saxagliptin (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
23697
Product name
Saxagliptin (hydrochloride)
Packaging
25mg
Price
$148
Updated
2024/03/01
Cayman Chemical
Product number
23697
Product name
Saxagliptin (hydrochloride)
Packaging
50mg
Price
$276
Updated
2024/03/01
Tocris
Product number
6507
Product name
Saxagliptinhydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$395
Updated
2021/12/16
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Saxagliptin hydrochloride Chemical Properties,Usage,Production

Description

Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 ?Human DPP-IV Ki = 0.6 nM.2

Uses

Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.

storage

Store at -20°C

References

Tahrani et al. (2009) Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus; Adv. Ther. 26 249 Augeri et al. (2005) Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes; J. Med. Chem. 48 5025

Saxagliptin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Saxagliptin hydrochloride Suppliers

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View Lastest Price from Saxagliptin hydrochloride manufacturers

Career Henan Chemical Co
Product
Saxagliptin hydrochloride 709031-78-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2020-01-13

709031-78-7, Saxagliptin hydrochlorideRelated Search:

Carboxymethoxylamine hemihydrochloride BOC-DL-PROLINE ETHYL ESTER (1R,3S,5R)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXAMIDE 2,2,2-TRIFLUOROACETIC ACID (1S,3R,5S)-2-tert-Butyl 3-ethyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2-tricyclo[3.3.1.13,7]dec-1-ylacetyl]-, (1S,3S,5S)- 1H-Pyrrole-1-carboxylic acid, 2-(aMinocarbonyl)-2,3-dihydro-, 1,1-diMethylethyl ester, (2S)- (S) - N- Boc- adamantylglycine (S)-1-Boc-2,3-dihydro-2-pyrrolecarboxylic acid ethyl ester 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)- N-Boc-L-trans-4,5-Methanoproline (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester (1S,3S,5S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID DSLXQSYLYSTVKT-ONZQNKQFSA-N 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3R,5S)- Saxagliptin O-β-D-glucuronide 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3S,5R)- N-Boc-L-trans-4,5-methanoproline ethyl ester

  • Saxagliptin hydrochloride
  • (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrochloride
  • (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
  • Saxagliptin HCL salt
  • Saxaint-S
  • 2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-,monohydrochloride, (1S,3S,5S)-
  • 709031-78-7
  • C18H25N3O2HCl
  • Saxagliptin Hydrochloride