2-chloro-3-cyclopropylpyridine

Product Name: 2-chloro-3-cyclopropylpyridine
CAS No.: 865664-04-6
Chemical Name: 2-chloro-3-cyclopropylpyridine
Synonyms: 2-chloro-3-cyclopropylpyridine;Pyridine, 2-chloro-3-cyclopropyl-
CBNumber: CB42631295
Molecular Formula: C8H8ClN
Formula Weight: 153.61
MOL File: 865664-04-6.mol

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2-chloro-3-cyclopropylpyridine Property

Boiling point:: 219.4±28.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.79±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0363434
Product name: 2-CHLORO-3-CYCLOPROPYLPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $500.16
Updated: 2021/12/16

AK Scientific

Product number: 8034DA
Product name: 2-Chloro-3-cyclopropylpyridine
Packaging: 5g
Price: $1446
Updated: 2021/12/16

Ambeed

Product number: A314752
Product name: 2-Chloro-3-cyclopropylpyridine
Purity: 95%
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Ambeed

Product number: A314752
Product name: 2-Chloro-3-cyclopropylpyridine
Purity: 95%
Packaging: 250mg
Price: $108
Updated: 2021/12/16

aablocks

Product number: AA00IE1R
Product name: 2-Chloro-3-cyclopropylpyridine
Purity: 95+%
Packaging: 250mg
Price: $188
Updated: 2021/12/16

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2-chloro-3-cyclopropylpyridine Chemical Properties,Usage,Production

Synthesis

78607-36-0

411235-57-9

865664-04-6

GENERAL STEPS: 2-chloro-3-iodopyridine (2.39 g, 9.98 mmol), cyclopropylboronic acid (860 mg, 10 mmol) and potassium carbonate (4.14 g, 30.0 mmol) were suspended in 1,4-dioxane (50 mL) under nitrogen protection. Tetrakis(triphenylphosphine)palladium(0) (1.16 g, 1.00 mmol) was subsequently added as a catalyst. The reaction mixture was stirred vigorously in an oil bath at 120°C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (50 mL) and filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was concentrated under reduced pressure and the crude product obtained was purified by silica gel column chromatography (elution gradient: 10% to 30% petroleum ether solution of ethyl acetate) to give 2-chloro-3-cyclopropylpyridine as a colorless oil. Yield: 1 g (6 mmol, 60% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.20 (dd, J = 4.7, 1.8 Hz, 1H), 7.24-7.28 (m, 1H), 7.14 (br dd, J = 7.6, 4.8 Hz, 1H), 2.12-2.21 (m, 1H), 1.04-1.11 (m, 2H), 0.67 -0.72 (m, 2H).

References

[1] Patent: WO2014/207601, 2014, A1. Location in patent: Page/Page column 70; 72

2-chloro-3-cyclopropylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-3-cyclopropylpyridine Suppliers

China 24 India 1 United States 3 Global 28

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865664-04-6, 2-chloro-3-cyclopropylpyridineRelated Search:

2-chloro-3-cyclopropylpyridine

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865664-04-6