ChemicalBook > CAS DataBase List > 3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate

3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate

Product Name
3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate
CAS No.
1192189-69-7
Chemical Name
3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate
Synonyms
LX7101;CS-2042;LX7101 HCL;LX7101 (LX-7101);LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo;3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate;inhibit,Inhibitor,LX 7101,LX7101,Rho-associated protein kinase,Rho-associated kinase,ROCK,LX-7101,Rho-kinase,ROK;3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl N.N-dimethylcarbamate;LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate;N,N-Dimethylcarbamic acid 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester
CBNumber
CB42638542
Molecular Formula
C23H29N7O3
Formula Weight
451.52
MOL File
1192189-69-7.mol
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3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Property

Density 
1.327±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form 
solid
pka
13.96±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5103
Product name
LX7101
Purity
99.57%
Packaging
2mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-5103
Product name
LX7101
Purity
99.57%
Packaging
5mg
Price
$200
Updated
2021/12/16
ApexBio Technology
Product number
B5863
Product name
LX7101HCL
Packaging
2mg
Price
$205
Updated
2021/12/16
ChemScene
Product number
CS-5103
Product name
LX7101
Purity
99.57%
Packaging
10mg
Price
$350
Updated
2021/12/16
ApexBio Technology
Product number
B5863
Product name
LX7101HCL
Packaging
5mg
Price
$378
Updated
2021/12/16
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3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Chemical Properties,Usage,Production

Biological Activity

lim-kinases 1 and 2 (limk1 and limk2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments. rock, a kinase upstream of limk in the signaling cascade that regulates actin filament dynamics, are being investigated in the clinic for reduction of iop through relaxation of the trabecular meshwork. lx7101 is a dual lim-kinase and rock inhibitor for the treatment of glaucoma.

in vitro

lx7101 proved significantly more selective for limk2. in addition, lx7101 was screened against a panel of 403 kinases. moderate selectivity was observed in this screen (34 assays including limk2 and rock2 indicated that the kd is most likely <1 μm) [1].

in vivo

at a well-tolerated dose, lx7101 achieved additional reduction of iop compared to the 0.1% formulation and demonstrated a long duration of action, with iop not returning to baseline until more than 8 h postdose. more critically, lx7101 produced a significantly greater reduction of iop than either timolol or latanoprost [1].

IC 50

4.3, 32, 69 and 32 nm for limk2, kimk1, rock1 and rock2, respectivley

References

[1] harrison ba, almstead zy, burgoon h, gardyan m, goodwin nc, healy j, liu y, mabon r, marinelli b, samala l, zhang y, stouch tr, whitlock na, gopinathan s, mcknight b, wang s, patel n, wilson ag, hamman bd, rice ds, rawlins db. discovery and development of lx7101, a dual lim-kinase and rock inhibitor for the treatment of glaucoma. acs med chem lett. 2014 nov 24;6(1):84-8.

3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Suppliers

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1192189-69-7, 3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMateRelated Search:

4-(Azetidin-3-yl)-1-methylpiperidine 1,1'-CARBONYLDIPIPERIDINE trans 2-(1,6-Dimethylpiperidin-3-yl)propan-2-ol 1-phenethylpiperidin-4-ol Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate 3-Isobutylglutarimid 1-Hydroxypiperidine-2,6-dione 2,6-Dioxopiperidine-3-ammonium chloride 4-[(4-Chlorophenyl)-2-pyridinylmethoxy]-1-piperidinecarboxylic acid ethyl ester Desloratadine N-Hydroxypiperidine (3R,5R)-3-(Boc-amino)-5-methylpiperidine (3S,5R)-3-(Boc-aMino)-5-Methylpiperidine 4-(4-Fluorophenyl)-3-hydroxymethyl-1-methyl-piperidine N-BUTYL-2-PIPERIDINE CARBOXYLIC ACID 3-Difluromethyl-2-oxo-3-piperdinecarboxamide 4,4,6-trimethyl-1,3-oxazinane-2-thione 2-Piperidinone, 3-amino-3-(difluoromethyl)-

  • N,N-Dimethylcarbamic acid 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester
  • 3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate
  • LX7101
  • LX7101 HCL
  • LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo
  • 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl N.N-dimethylcarbamate
  • LX7101 (LX-7101)
  • CS-2042
  • LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate
  • Carbamic acid, N,N-dimethyl-, 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester
  • inhibit,Inhibitor,LX 7101,LX7101,Rho-associated protein kinase,Rho-associated kinase,ROCK,LX-7101,Rho-kinase,ROK
  • 1192189-69-7
  • C23H30ClN7O3