(3R,5R)-3-(Boc-amino)-5-methylpiperidine

Product Name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
CAS No.: 1227919-32-5
Chemical Name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
Synonyms: Nemonoxacin Impurity 10;Nenofloxacin impurity 17;Levocarnitine Impurity 51;Methisosildenafil Impurity 45;(3R,5R)-3-(Boc-amino)-5-methylpiperidine;3-Isoxazolecarboxylicacid,5-(8-methoxyphenyl)-;tert-Butyl((3R,5R)-5-methylpiperidin-3-yl)carbamate;tert-butyl N-[(3R,5R)-5-methylpiperidin-3-yl]carbamate;Carbamic acid, N-[(3R,5R)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester
CBNumber: CB83161858
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 1227919-32-5.mol

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(3R,5R)-3-(Boc-amino)-5-methylpiperidine Property

Boiling point:: 313.4±31.0 °C(Predicted)
Density: 1.00±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.38±0.40(Predicted)
InChI: InChI=1S/C11H22N2O2/c1-8-5-9(7-12-6-8)13-10(14)15-11(2,3)4/h8-9,12H,5-7H2,1-4H3,(H,13,14)/t8-,9-/m1/s1
InChIKey: CNALVHVMBXLLIY-RKDXNWHRSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@@H]1C[C@@H](C)CNC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B695398
Product name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
Packaging: 2.5mg
Price: $160
Updated: 2021/12/16

TRC

Product number: B695398
Product name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
Packaging: 25mg
Price: $1260
Updated: 2021/12/16

Synthonix

Product number: A13486
Product name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
Purity: 95+%
Packaging: 1g
Price: $2200
Updated: 2021/12/16

Matrix Scientific

Product number: 123517
Product name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
Purity: 95+%
Packaging: 1g
Price: $4472
Updated: 2021/12/16

Crysdot

Product number: CD11321286
Product name: (3R,5R)-3-(Boc-amino)-5-methylpiperidine
Purity: 95+%
Packaging: 1g
Price: $1736
Updated: 2021/12/16

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(3R,5R)-3-(Boc-amino)-5-methylpiperidine Chemical Properties,Usage,Production

Uses

(3R,5R)-3-(Boc-amino)-5-methylpiperidine is used in the synthetic preparation of amino(aminopyrimidinyl)indazoles as selective 3-phosphoinositide-dependent kinase-1 inhibitors and antitumor agents.

Synthesis

1227919-31-4

1227919-32-5

Step 1: tert-Butyl ((3R,5R)-1-benzyl-5-methylpiperidin-3-yl)carbamate (0.6 g, 1.971 mmol, see WO2004014893 for preparation) was dissolved in ethanol (10 mL) and palladium carbon (Pd(OH)2/C, 0.1 g) was added. The reaction mixture was stirred at room temperature and under an atmosphere of hydrogen at 1 atm. After 2 h, the palladium catalyst was removed by filtration and the solvent was subsequently evaporated to afford 0.45 g of tert-butyl ((3R,5R)-5-methylpiperidin-3-yl)carbamate as a colorless oil in >95% yield.

References

[1] Patent: US2010/144745, 2010, A1. Location in patent: Page/Page column 44
[2] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 53
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1871 - 1895

(3R,5R)-3-(Boc-amino)-5-methylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (3R,5R)-3-(Boc-amino)-5-methylpiperidine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (3R,5R)-3-(Boc-amino)-5-methylpiperidine 1227919-32-5
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-07

1227919-32-5, (3R,5R)-3-(Boc-amino)-5-methylpiperidineRelated Search:

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(3R,5R)-3-(Boc-amino)-5-methylpiperidine

tert-Butyl((3R,5R)-5-methylpiperidin-3-yl)carbamate

tert-butyl N-[(3R,5R)-5-methylpiperidin-3-yl]carbamate

Carbamic acid, N-[(3R,5R)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester

3-Isoxazolecarboxylicacid,5-(8-methoxyphenyl)-

Methisosildenafil Impurity 45

Nemonoxacin Impurity 10

Nenofloxacin impurity 17

Levocarnitine Impurity 51

1227919-32-5