3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate

Product Name: 3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate
CAS No.: 1192189-69-7
Chemical Name: 3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate
Synonyms: LX7101;CS-2042;LX7101 HCL;LX7101 (LX-7101);LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo;3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate;inhibit,Inhibitor,LX 7101,LX7101,Rho-associated protein kinase,Rho-associated kinase,ROCK,LX-7101,Rho-kinase,ROK;3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl N.N-dimethylcarbamate;LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate;N,N-Dimethylcarbamic acid 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester
CBNumber: CB42638542
Molecular Formula: C23H29N7O3
Formula Weight: 451.52
MOL File: 1192189-69-7.mol

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3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Property

Density: 1.327±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form: solid
pka: 13.96±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5103
Product name: LX7101
Purity: 99.57%
Packaging: 2mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-5103
Product name: LX7101
Purity: 99.57%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ApexBio Technology

Product number: B5863
Product name: LX7101HCL
Packaging: 2mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-5103
Product name: LX7101
Purity: 99.57%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ApexBio Technology

Product number: B5863
Product name: LX7101HCL
Packaging: 5mg
Price: $378
Updated: 2021/12/16

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3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Chemical Properties,Usage,Production

Biological Activity

lim-kinases 1 and 2 (limk1 and limk2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments. rock, a kinase upstream of limk in the signaling cascade that regulates actin filament dynamics, are being investigated in the clinic for reduction of iop through relaxation of the trabecular meshwork. lx7101 is a dual lim-kinase and rock inhibitor for the treatment of glaucoma.

in vitro

lx7101 proved significantly more selective for limk2. in addition, lx7101 was screened against a panel of 403 kinases. moderate selectivity was observed in this screen (34 assays including limk2 and rock2 indicated that the kd is most likely <1 μm) [1].

in vivo

at a well-tolerated dose, lx7101 achieved additional reduction of iop compared to the 0.1% formulation and demonstrated a long duration of action, with iop not returning to baseline until more than 8 h postdose. more critically, lx7101 produced a significantly greater reduction of iop than either timolol or latanoprost [1].

IC 50

4.3, 32, 69 and 32 nm for limk2, kimk1, rock1 and rock2, respectivley

References

[1] harrison ba, almstead zy, burgoon h, gardyan m, goodwin nc, healy j, liu y, mabon r, marinelli b, samala l, zhang y, stouch tr, whitlock na, gopinathan s, mcknight b, wang s, patel n, wilson ag, hamman bd, rice ds, rawlins db. discovery and development of lx7101, a dual lim-kinase and rock inhibitor for the treatment of glaucoma. acs med chem lett. 2014 nov 24;6(1):84-8.

3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate Suppliers

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1192189-69-7, 3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMateRelated Search:

4-(Azetidin-3-yl)-1-methylpiperidine 1,1'-CARBONYLDIPIPERIDINE trans 2-(1,6-Dimethylpiperidin-3-yl)propan-2-ol 1-phenethylpiperidin-4-ol Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate 3-Isobutylglutarimid 1-Hydroxypiperidine-2,6-dione 2,6-Dioxopiperidine-3-ammonium chloride 4-[(4-Chlorophenyl)-2-pyridinylmethoxy]-1-piperidinecarboxylic acid ethyl ester Desloratadine N-Hydroxypiperidine (3R,5R)-3-(Boc-amino)-5-methylpiperidine (3S,5R)-3-(Boc-aMino)-5-Methylpiperidine 4-(4-Fluorophenyl)-3-hydroxymethyl-1-methyl-piperidine N-BUTYL-2-PIPERIDINE CARBOXYLIC ACID 3-Difluromethyl-2-oxo-3-piperdinecarboxamide 4,4,6-trimethyl-1,3-oxazinane-2-thione 2-Piperidinone, 3-amino-3-(difluoromethyl)-

N,N-Dimethylcarbamic acid 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester

3-(4-(aMinoMethyl)-1-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidine-4-carboxaMido)phenyl diMethylcarbaMate

LX7101

LX7101 HCL

LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo

3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl N.N-dimethylcarbamate

LX7101 (LX-7101)

CS-2042

LX7101 (3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate

Carbamic acid, N,N-dimethyl-, 3-[[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbonyl]amino]phenyl ester

inhibit,Inhibitor,LX 7101,LX7101,Rho-associated protein kinase,Rho-associated kinase,ROCK,LX-7101,Rho-kinase,ROK

1192189-69-7

C23H30ClN7O3