1,8-Dichloroisoquinoline
- Product Name
- 1,8-Dichloroisoquinoline
- CAS No.
- 848841-64-5
- Chemical Name
- 1,8-Dichloroisoquinoline
- Synonyms
- 1,8-Dichloroisoquinoline;Isoquinoline, 1,8-dichloro-;1,8-Dichloroisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB42652793
- Molecular Formula
- C9H5Cl2N
- Formula Weight
- 198.05
- MOL File
- 848841-64-5.mol
1,8-Dichloroisoquinoline Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- D439810
- Product name
- 1,8-Dichloroisoquinoline
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD142519
- Product name
- 1,8-Dichloroisoquinoline
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD142519
- Product name
- 1,8-Dichloroisoquinoline
- Packaging
- 1g
- Price
- $177
- Updated
- 2021/12/16
- Product number
- FD142519
- Product name
- 1,8-Dichloroisoquinoline
- Packaging
- 2g
- Price
- $308
- Updated
- 2021/12/16
- Product number
- HCH0362087
- Product name
- 1,8-DICHLOROISOQUINOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $338.1
- Updated
- 2021/12/16
1,8-Dichloroisoquinoline Chemical Properties,Usage,Production
Synthesis
34784-07-1
848841-64-5
Procedure for the synthesis of 1,8-dichloroisoquinoline: To a solution of 8-chloroisoquinoline (11 g, 54 mmol) in dichloromethane (200 mL) was added m-chloroperoxybenzoic acid (MCPBA, 25 g, 112 mmol) in batches. The reaction mixture was stirred for 3 hours and then ether (400 mL) and hexane (1 L) were added. The mixture was stirred overnight and subsequently concentrated under vacuum. Ether (200 mL) and hexane (400 mL) were added to the concentrate and stirred again overnight. The precipitate was collected by filtration, air dried and mixed with silica gel (20 g) and toluene (150 mL). The mixture was heated to reflux for 3 hours and neutralized with sodium bicarbonate (NaHCO3) when the reaction was complete. The reaction mixture was extracted with dichloromethane (CH2Cl2) and the organic layer was dried over anhydrous sodium sulfate and concentrated in vacuum to give 1,8-dichloroisoquinoline (8 g, 72% yield). Mass spectrum (MS): 198.
References
[1] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 67-68
1,8-Dichloroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
1,8-Dichloroisoquinoline Suppliers
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