VS-5584

ChemicalBook > CAS DataBase List > VS-5584

Product Name: VS-5584
CAS No.: 1246560-33-7
Chemical Name: VS-5584
Synonyms: SB-2343;VS-5584 (SB2343);SB2343;CS-875;SB 2343;VS-5584;VS-5584, >=98%;VS-5584 VS5584;VS-5584 USP/EP/BP;VS-5584 (SB2343);VS-5584;VS5584;VS 5584
CBNumber: CB42666411
Molecular Formula: C17H22N8O
Formula Weight: 354.41
MOL File: 1246560-33-7.mol

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VS-5584 Property

Boiling point:: 687.2±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥17.7 mg/mL in DMSO; ≥4.71 mg/mL in EtOH with ultrasonic
form: solid
pka: 4.53±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16294
Product name: VS-5584
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16294
Product name: VS-5584
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 16294
Product name: VS-5584
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

ChemScene

Product number: CS-1202
Product name: VS-5584
Purity: 98.15%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-1202
Product name: VS-5584
Purity: 98.15%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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VS-5584 Chemical Properties,Usage,Production

Description

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.

target

mTOR

VS-5584 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from VS-5584 manufacturers

Career Henan Chemical Co

Product: VS-5584 1246560-33-7
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1246560-33-7, VS-5584Related Search:

VX-745 USP/EP/BP VX 702 Vps VR23 VRT752271 Defactinib BKM120 (NVP-BKM120, Buparlisib) ABT 737 IPI 145 IC-87114 XL147

2-Pyrimidinamine, 5-[8-methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-

5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine VS-5584

VS-5584, >=98%

VS-5584

SB 2343

SB2343

SB-2343

VS-5584 (SB2343)

5-(9-Isopropyl-8-Methyl-2-Morpholin-4-yl-9H-purin-6-yl)-pyriMidin-2-ylaMine

5-(9-ISOPROPYL-8-METHYL-2-MORPHOLINO-9H-PURIN-6-YL)PYRIMIDIN-2-AMINE

5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine

VS-5584 (SB2343);VS-5584;VS5584;VS 5584

SB-2343; VS5584; VS 5584; SB2343; SB 2343

CS-875

5-[9-Isopropyl-8-methyl-2-(morpholin-4-yl)purin-6-yl]pyrimidin-2-amine

VS-5584 USP/EP/BP

VS-5584 VS5584

1246560-33-7

C17H22N8O

Akt

mTOR

PI3K

PI3K/Akt/mTOR

Inhibitors