ChemicalBook > CAS DataBase List > AMD 070 hydrochloride

AMD 070 hydrochloride

Product Name
AMD 070 hydrochloride
CAS No.
880549-30-4
Chemical Name
AMD 070 hydrochloride
Synonyms
AMD-070 HCl;Mavorixafor HCl;AMD070 hydrochloride;AMD 070 hydrochloride;AMD-11070 HYDROCHLORIDE;AMD-070 (hydrochloride);AMD-070 (HCl 75%(w/w%));Mavorixafor (AMD-070) triHCl;AMD 070 Hydrochloride - Bio-X ?;AMD-070 hydrochloride(Mavorixafor)
CBNumber
CB42666587
Molecular Formula
C21H28ClN5
Formula Weight
385.94
MOL File
880549-30-4.mol
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AMD 070 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3266
Product name
AMD070 hydrochloride
Purity
≥98% (HPLC)
Packaging
5MG
Price
$71.1
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3266
Product name
AMD070 hydrochloride
Purity
≥98% (HPLC)
Packaging
25MG
Price
$360
Updated
2025/07/31
TRC
Product number
B202975
Product name
N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamineMonohydrochloride
Packaging
1mg
Price
$110
Updated
2021/12/16
ApexBio Technology
Product number
A3174
Product name
AMD-070hydrochloride
Packaging
5mg
Price
$140
Updated
2021/12/16
ApexBio Technology
Product number
A3174
Product name
AMD-070hydrochloride
Packaging
10mg
Price
$250
Updated
2021/12/16
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AMD 070 hydrochloride Chemical Properties,Usage,Production

Uses

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine Monohydrochloride is a potent and selective antagonist of CXCR4. It is also an inhibitor of X4-tropic HIV virus.

Biological Activity

AMD070 (AMD11070) is an orally active, reversible and selective CXCR4 (CD184, fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) th at inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM.

in vivo

Mavorixafor (2 mg/kg; po; once a day; for 49 days) hydrochloride significantly inhibits the lung metastasis of B88 SDF 1 cells in nude mice[2].

Animal Model:BALB/c nude mice (8 weeks of age) injected with B88-SDF-1 cells[2]
Dosage:2 mg/kg
Administration:Oral administration; once a day; for 49 days
Result:A significant reduction in the number of metastatic lung nodules was observed in the mice.

IC 50

125I-CXCL12-CXCR4: 13 nM (IC50); HIV-1 (NL4.3 strain): 1 nM (IC50, In MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC50, In PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, In MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, In PBMCs)

AMD 070 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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AMD 070 hydrochloride Suppliers

China 49 United States 8 Global 57
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.
Tel
028-028-37664989 15900794981
Email
jingzhichem@163.com
Country
China
ProdList
537
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
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View Lastest Price from AMD 070 hydrochloride manufacturers

Honest Joy Holdings Limited
Product
AMD-070 hydrochloride 880549-30-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98.7%
Supply Ability
100 tons
Release date
2022-01-13

880549-30-4, AMD 070 hydrochlorideRelated Search:


  • AMD 070 hydrochloride
  • AMD-070 (hydrochloride)
  • AMD070 HYDROCHLORIDE; AMD 070 HYDROCHLORIDE
  • AMD070 hydrochloride
  • AMD-070 (HCl 75%(w/w%))
  • N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine monohydrochloride
  • AMD-070 HCl
  • N1-(1H-Benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine hydrochloride
  • AMD-11070 HYDROCHLORIDE
  • AMD-070 hydrochloride(Mavorixafor)
  • Mavorixafor (AMD-070) triHCl
  • Mavorixafor HCl
  • (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride
  • AMD-070 hydrochloride, 10 mM in DMSO
  • AMD 070 Hydrochloride - Bio-X ?
  • AMD-070 hydrochloride (AMD-11070 hydrochloride)
  • 880549-30-4
  • C21H27N5HCl
  • C21H30Cl3N5