CEP-28122

Product Name: CEP-28122
CAS No.: 1022958-60-6
Chemical Name: CEP-28122
Synonyms: CS-1605;CEP-28122;CEP 28122;CEP28122;(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-bicyclo[2.2.1]hept-5-ene-2-carboxamide;Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-;(1S,2S,3R,4R)-3-[5-chloro-2-((S)-1-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-2-ylamino)pyrimidin-4-ylamino]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide
CBNumber: CB42666714
Molecular Formula: C28H35ClN6O3
Formula Weight: 539.07
MOL File: 1022958-60-6.mol

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CEP-28122 Property

Boiling point:: 786.9±70.0 °C(Predicted)
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤30mg/ml in DMSO;12mg/ml in dimethyl formamide
form: crystalline solid
pka: 16.24±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18406
Product name: CEP-28122
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18406
Product name: CEP-28122
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18406
Product name: CEP-28122
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 18406
Product name: CEP-28122
Purity: ≥98%
Packaging: 25mg
Price: $745
Updated: 2024/03/01

TRC

Product number: C256650
Product name: CEP-28122
Packaging: 25mg
Price: $10725
Updated: 2021/12/16

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CEP-28122 Chemical Properties,Usage,Production

Uses

CEP-28122 is used as an orally efficacious inhibitor of (ALK), analplastic lymphoma kinase, in the treatment of cancer.

Biological Activity

cep-28122, a highly potent, selective, orally bioavailable inhibitor of alk, dampens the phosphorylation of alk and alk substrates in cells and triggers cytotoxicity or growth inhibition of alk-positive cancer cells with a favorable pharmaceutical and pharmacokinetic profile and selective pharmacologic efficacy. cep-28122 blocks alk tyrosine phosphorylation in tumor xenografts in mice. alk, which is constitutively activated in many human cancer types because of point mutations, gene amplification, and chromosomal translocations, has emerged as an excellent molecular target for cancer therapy.

in vitro

cep-28122, concentration-dependently, triggered growth inhibition/cytotoxicity of alk-positive anaplastic large-cell lymphoma (alcl) via inhibiting nucleophosmin (npm) -alk tyrosine (664) phosphorylation. due to the cep-28122 treatment, eml4-alk tyrosine phosphorylation was blocked in non-small cell lung cancer (nsclc) nci-h2228 and nci-h3122 cells and full-length alk receptor tyrosine phosphorylation was inhibited in neuroblastoma cell line nb-1 cells [1].

in vivo

severe combined immunodeficient (scid) mice bearing sup-m2 (b) or nu/nu mice bearing colon carcinoma hct-116 (c) subcutaneous tumor xenografts were administered orally with cep-28122 at 3, 10, or 30 mg/kg for 24 days. cep-28122 showed inhibition of alk tyrosine phosphorylation in a dose-dependent manner in tumor xenografts in mice when treated at 30 mg/kg. moreover, cep-28122 displayed dose-dependent antitumor activity in alk-positive alcl, nsclc, and neuroblastoma tumor xenografts in mice when administered orally at 30 mg/kg or higher [1].

IC 50

1.9 nm: blocks anaplastic lymphoma kinase (alk).

References

[1]. cheng, m., quail, m., gingrich, d., ott, g., lu, l., & wan, w. et al. cep-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. molecular cancer therapeutics. 2011; 11(3): 670-679.

CEP-28122 Preparation Products And Raw materials

Raw materials

Preparation Products

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CEP-28122 Suppliers

Canada 1 China 50 India 1 United States 11 Global 63

Shanghai Boyle Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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MedChemexpress LLC

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AdooQ BioScience, LLC

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Shanghai TaoSu Biochemical Technology Co., Ltd.

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AdooQ Bioscience CHINA

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Shanghai YuanQi Biotechnology Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
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View Lastest Price from CEP-28122 manufacturers

Career Henan Chemical Co

Product: CEP-28122 1022958-60-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-31

1022958-60-6, CEP-28122Related Search:

CS-1605

CEP 28122;CEP28122

CEP-28122

(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-bicyclo[2.2.1]hept-5-ene-2-carboxamide

(1S,2S,3R,4R)-3-[5-chloro-2-((S)-1-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-2-ylamino)pyrimidin-4-ylamino]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide

Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-

1022958-60-6

C28H35ClN6O3

Inhibitors

Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals