ChemicalBook > CAS DataBase List > HM 30181A

HM 30181A

Product Name
HM 30181A
CAS No.
849675-66-7
Chemical Name
HM 30181A
Synonyms
HM30181;HM 30181A;HM30181;HM30181A;HM30181(Encequidar);Encequidar (HM-30181;Encequidar, 10 mM in DMSO;N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide;MDR1,P-gp,Cluster of differentiation 243,inhibit,HM 30181,Encequidar,P-glycoprotein,Multidrug resistance protein 1,Inhibitor,CD243,Pgp,ABCB1,HM-30181;4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-
CBNumber
CB42667519
Molecular Formula
C38H36N6O7
Formula Weight
688.73
MOL File
849675-66-7.mol
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HM 30181A Property

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:30.0(Max Conc. mg/mL);43.56(Max Conc. mM)
form 
A crystalline solid
pka
7.95±0.70(Predicted)
color 
Light yellow to yellow
InChIKey
AHJUHHDDCJQACA-UHFFFAOYSA-N
SMILES
C1(C(NC2=CC(OC)=C(OC)C=C2C2=NN(C3=CC=C(CCN4CCC5=C(C4)C=C(OC)C(OC)=C5)C=C3)N=N2)=O)OC2=CC=CC=C2C(=O)C=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

ChemScene
Product number
CS-6194
Product name
Encequidar
Purity
≥98.0%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-6194
Product name
Encequidar
Purity
≥98.0%
Packaging
50mg
Price
$504
Updated
2021/12/16
ChemScene
Product number
CS-6194
Product name
Encequidar
Purity
≥98.0%
Packaging
100mg
Price
$708
Updated
2021/12/16
DC Chemicals
Product number
DC10414
Product name
HM30181(Encequidar)
Purity
>98%
Packaging
250mg
Price
$800
Updated
2021/12/16
Crysdot
Product number
CD11046631
Product name
HM-30181-A
Purity
95+%
Packaging
5mg
Price
$69
Updated
2021/12/16
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HM 30181A Chemical Properties,Usage,Production

Uses

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

in vivo

PET scans with the Pgp substrate (R)-[11C]NSC 657799 in FVB wild-type mice pretreated i.v. with Encequidar (HM30181) (10 or 21 mg/kg) failes to show significant increases in (R)-[11C]NSC 657799 brain uptake compared with vehicle treated animals[1]. Encequidar (HM30181) inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. Encequidar (HM30181) increases the oral bioavailability of co-administered NSC 125973 by more than 12 times in rats[2].

References

[1] Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27. DOI:10.1016/j.ejphar.2012.09.013
[2] Kim TE, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014 Sep;78(3):556-64. DOI:10.1111/bcp.12368

HM 30181A Preparation Products And Raw materials

Raw materials

Preparation Products

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HM 30181A Suppliers

China 63 United States 5 Global 68
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
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info@porsefinechemical.com
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China
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1941
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2987
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58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
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58
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2944
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58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
Fax
0755-85201366
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sales@regentsciences.com
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China
ProdList
9751
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58

849675-66-7, HM 30181ARelated Search:


  • HM 30181A
  • HM30181
  • HM30181;HM30181A
  • 4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-
  • HM30181(Encequidar)
  • Encequidar (HM-30181
  • MDR1,P-gp,Cluster of differentiation 243,inhibit,HM 30181,Encequidar,P-glycoprotein,Multidrug resistance protein 1,Inhibitor,CD243,Pgp,ABCB1,HM-30181
  • Encequidar, 10 mM in DMSO
  • N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide
  • 849675-66-7
  • C38H36N6O7