HM 30181A
- Product Name
- HM 30181A
- CAS No.
- 849675-66-7
- Chemical Name
- HM 30181A
- Synonyms
- HM30181;HM 30181A;HM30181;HM30181A;HM30181(Encequidar);Encequidar (HM-30181;Encequidar, 10 mM in DMSO;N-(2-(2-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide;MDR1,P-gp,Cluster of differentiation 243,inhibit,HM 30181,Encequidar,P-glycoprotein,Multidrug resistance protein 1,Inhibitor,CD243,Pgp,ABCB1,HM-30181;4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-
- CBNumber
- CB42667519
- Molecular Formula
- C38H36N6O7
- Formula Weight
- 688.73
- MOL File
- 849675-66-7.mol
HM 30181A Property
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:30.0(Max Conc. mg/mL);43.56(Max Conc. mM)
- form
- A crystalline solid
- pka
- 7.95±0.70(Predicted)
- color
- Light yellow to yellow
- InChIKey
- AHJUHHDDCJQACA-UHFFFAOYSA-N
- SMILES
- C1(C(NC2=CC(OC)=C(OC)C=C2C2=NN(C3=CC=C(CCN4CCC5=C(C4)C=C(OC)C(OC)=C5)C=C3)N=N2)=O)OC2=CC=CC=C2C(=O)C=1
N-Bromosuccinimide Price
- Product number
- CS-6194
- Product name
- Encequidar
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-6194
- Product name
- Encequidar
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $504
- Updated
- 2021/12/16
- Product number
- CS-6194
- Product name
- Encequidar
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $708
- Updated
- 2021/12/16
- Product number
- DC10414
- Product name
- HM30181(Encequidar)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- CD11046631
- Product name
- HM-30181-A
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $69
- Updated
- 2021/12/16
HM 30181A Chemical Properties,Usage,Production
Uses
Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.
in vivo
PET scans with the Pgp substrate (R)-[11C]NSC 657799 in FVB wild-type mice pretreated i.v. with Encequidar (HM30181) (10 or 21 mg/kg) failes to show significant increases in (R)-[11C]NSC 657799 brain uptake compared with vehicle treated animals[1]. Encequidar (HM30181) inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. Encequidar (HM30181) increases the oral bioavailability of co-administered NSC 125973 by more than 12 times in rats[2].
References
[1] Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27. DOI:10.1016/j.ejphar.2012.09.013
[2] Kim TE, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014 Sep;78(3):556-64. DOI:10.1111/bcp.12368
HM 30181A Preparation Products And Raw materials
Raw materials
Preparation Products
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