GNF5

Product Name: GNF5
CAS No.: 778277-15-9
Chemical Name: GNF5
Synonyms: GNF5;GNF-5;GNF 5;CS-1437;GNF 5; GNF5;GNF-5, >=98%;GNF5 USP/EP/BP;GNF-5 , 778277-15-9;GNF-5, 10 mM in DMSO;Bcr-abl Inhibitor III
CBNumber: CB42667791
Molecular Formula: C20H17F3N4O3
Formula Weight: 418.37
MOL File: 778277-15-9.mol

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GNF5 Property

Boiling point:: 612.4±55.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: soluble10mg/mL (clear solution)
pka: 13.36±0.46(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 22-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0511
Product name: GNF-5
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $133
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0511
Product name: GNF-5
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $440
Updated: 2022/05/15

Cayman Chemical

Product number: 16254
Product name: GNF-5
Purity: ≥95%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16254
Product name: GNF-5
Purity: ≥95%
Packaging: 10mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 16254
Product name: GNF-5
Purity: ≥95%
Packaging: 25mg
Price: $108
Updated: 2024/03/01

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GNF5 Chemical Properties,Usage,Production

Uses

GNF-5 is a selective and allosteric Bcr-Abl inhibitor. It is a COVID19-related research product.

Biological Activity

GNF-5 is a BRC-Abl inhibitor.

in vivo

GNF-5 (5 mg/kg iv. or 20 mg/kg oral) has suitable pharmacokinetic parameters^[1].
GNF-5 (oral, 50 or 100 mg/kg, twice daily, for 7 days) shows efficacious in vivo but can observe relapses^[1].
GNF-5 (75 mg/kg, b.i.d) inhibits T315I Bcr-Abl combination with nilotinib in vivo^[1].

Animal Model:

Male Balb/c mice^[1]

Dosage:

5 mg/kg, 20 mg/kg

Administration:

5 mg/kg intravenously or 20 mg/kg orally

Result:

AUC_inf (min*ug/mL)	292.37
AUC_inf (hrs*nM	11647
C_max(nM)	4386.08
T_max(hrs)	0.50
Clast (nM)	636.16
T_1/2(hrs)	2.30
V_ss(L/kg)	9.18
F (%)	44.82

Animal Model:	p210 xenograft model^[1]
Dosage:	50 or 100 mg/kg
Administration:	oral, twice daily, for 7 days
Result:	Could normalize blood counts and spleen size.

Animal Model:	Bone marrow transduction/transplantation model^[1]
Dosage:	75 mg/kg
Administration:	twice daily
Result:	Showed no significant response (alone). Showed no toxicity and had a strong and sustained inhibition of Bcr-Abl-mediated signaling combination with nilotinib.

storage

Store at +4°C

GNF5 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNF5 Suppliers

China 90 India 2 United Kingdom 1 United States 18 Global 111

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD

Tel: 13816107857
Fax: qq: 276312098
Email: sales@fortunechem-sh.com
Country: China
ProdList: 984
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
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Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
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Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
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LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

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View Lastest Price from GNF5 manufacturers

Career Henan Chemical Co

Product: GNF5 778277-15-9
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

778277-15-9, GNF5Related Search:

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GNF 5

GNF5

GNF-5

N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

ert-butyl 2-oxopiperidine-1-carboxylate

GNF 5 N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5

GNF-5, >=98%

CS-1437

GNF 5; GNF5

GNF-5 , 778277-15-9

6-ISOPROPOXY-1,3-BENZOTHIAZOL-2-AMINE

Benzamide, N-(2-hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-

GNF5 USP/EP/BP

N-(2-hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide

GNF-5, 10 mM in DMSO

Bcr-abl Inhibitor III

778277-15-9

Inhibitors