GNF-2

Product Name: GNF-2
CAS No.: 778270-11-4
Chemical Name: GNF-2
Synonyms: GNF-2;CS-569;GNF2;GNF 2;GNF 2, >=98%;GNF-2 USP/EP/BP;Bcr-abl Inhibitor;GNF-2, 10 mM in DMSO;Bcr-abl Inhibitor - CAS 778270-11-4 - Calbiochem;3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
CBNumber: CB4973102
Molecular Formula: C18H13F3N4O2
Formula Weight: 374.32
MOL File: 778270-11-4.mol

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GNF-2 Property

storage temp.: 2-8°C
solubility: H2O: <2mg/mL
form: White solid
color: off-white
Water Solubility: H2O: <2mg/mL
DMSO: ≥5mg/mL
InChI: 1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChIKey: WEVYNIUIFUYDGI-UHFFFAOYSA-N
SMILES: NC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G9420
Product name: GNF-2
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $249
Updated: 2025/07/31

Sigma-Aldrich

Product number: G9420
Product name: GNF-2
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $934
Updated: 2023/01/07

Cayman Chemical

Product number: 16253
Product name: GNF-2
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16253
Product name: GNF-2
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16253
Product name: GNF-2
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

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GNF-2 Chemical Properties,Usage,Production

Description

GNF-2 is an allosteric inhibitor of Bcr-Abl (IC₅₀ = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 μM. It inhibits proliferation of Ba/F3 cells (IC₅₀ = 138 nM). GNF-2 (10 μM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion. It inhibits LPS-induced production of nitric oxide (NO) and TNF-α in BV-2 microglia when used at concentrations of 10 and 20 μM. GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; ).

Uses

Bcr-abl Inhibitor is an inhibitor of c-Abl and Bcr-abl activity. It is a COVID19-related research product.

Definition

ChEBI: 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide is a member of pyrimidines.

General Description

A cell-permeable and reverisble pyrimidine compound that binds to the c-abl myristoyl binding pocket and acts as an allosteric, non-ATP-competitive inhibitor of cellular Bcr-abl activity and Bcr-abl-dependent cellular functions. Exhibits little inhibitory effect against a panel of 63 kinases even at concentration as high as 10 μM. Exhibits potent and selective antiproliferative activity toward Bcr-abl-expressing cells (IC₅₀ = 138 nM, 194 nM, 268 nM and 273 nM in Ba/F3.p210, Ba/F3.p^185Y253H, SUP-B15 and Ba/F3.p^210E255V, and K562, respectively). Brij-35 is reported to mask the inhibitory effect of GNF-2 in cell-free c-abl and Bcr-abl kinase assays.

Biochem/physiol Actions

GNF-2 belongs to a new class of Bcr-abl inhibitors. GNF-2 appears to bind to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. It inhibits Bcr-abl phosphorylation with an IC50 of 267 nM, but does not inhibit a panel of 63 other kinases, including native c-Abl, and shows complete lack of toxicity towards cells not expressing Bcr-Abl. GNF-2 shows great potential for a new class of inhibitor to study Bcr-abl activity and to treat resistant Chronic myelogenous leukemia (CML), which is caused the Bcr-Abl oncoprotein.

References

[1] FRANCISCO J ADRIáN. Allosteric inhibitors of Bcr-abl–dependent cell proliferation[J]. Nature chemical biology, 2006, 2 2: 95-102. DOI: 10.1038/nchembio760
[2] JEANNE M SISK Carolyn E M Matthew B Frieman. Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors.[J]. Journal of General Virology, 2018, 99 5: 619-630. DOI: 10.1099/jgv.0.001047
[3] GYUN JEE SONG. A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain.[J]. Frontiers in Pharmacology, 2019: 543. DOI: 10.3389/fphar.2019.00543

GNF-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNF-2 Suppliers

China 126 India 2 Switzerland 1 United Kingdom 1 United States 23 Global 153

Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Jinan Trio PharmaTech Co., Ltd.

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Fax: +86 (531) 55696010 QQ 1762738062
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China Langchem Inc.

Tel: 0086-21-58956006
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
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Shanghai Topbiochem Technology Co., Ltd

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NCE Biomedical Co.,Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

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Nanjing Norris-Pharm Technology Co., Ltd

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Haoyuan Chemexpress Co., Ltd.

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View Lastest Price from GNF-2 manufacturers

Career Henan Chemical Co

Product: GNF-2 778270-11-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

778270-11-4, GNF-2Related Search:

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3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-2

GNF-2 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

GNF 2, >=98%

3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE

Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-

GNF-2

Bcr-abl Inhibitor

3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Bcr-abl Inhibitor - CAS 778270-11-4 - Calbiochem

CS-569

GNF2;GNF 2

GNF-2 USP/EP/BP

SARS coronavirus,GNF-2,allosteric,GNF 2,non-ATP competitive inhibitor,Ba/F3.p185Y253H,Bcr-Abl,Ba/F3.p210E255V,SARS-CoV,Ba/F3.p210,bone erosion,Inhibitor,inhibit

GNF-2, 10 mM in DMSO

778270-11-4

C18H13F3N4O2

Inhibitors