GNF-2

ChemicalBook > CAS DataBase List > GNF-2

Product Name: GNF-2
CAS No.: 778270-11-4
Chemical Name: GNF-2
Synonyms: GNF-2;CS-569;GNF2;GNF 2;GNF 2, >=98%;GNF-2 USP/EP/BP;Bcr-abl Inhibitor;GNF-2, 10 mM in DMSO;Bcr-abl Inhibitor - CAS 778270-11-4 - Calbiochem;3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
CBNumber: CB4973102
Molecular Formula: C18H13F3N4O2
Formula Weight: 374.32
MOL File: 778270-11-4.mol

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GNF-2 Property

storage temp.: 2-8°C
solubility: H2O: <2mg/mL
form: White solid
color: off-white
Water Solubility: H2O: <2mg/mL
DMSO: ≥5mg/mL

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G9420
Product name: GNF-2
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $242
Updated: 2024/03/01

Sigma-Aldrich

Product number: G9420
Product name: GNF-2
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $934
Updated: 2023/01/07

Cayman Chemical

Product number: 16253
Product name: GNF-2
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16253
Product name: GNF-2
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16253
Product name: GNF-2
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

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GNF-2 Chemical Properties,Usage,Production

Description

GNF-2 is an allosteric inhibitor of Bcr-Abl (IC₅₀ = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 μM. It inhibits proliferation of Ba/F3 cells (IC₅₀ = 138 nM). GNF-2 (10 μM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion. It inhibits LPS-induced production of nitric oxide (NO) and TNF-α in BV-2 microglia when used at concentrations of 10 and 20 μM. GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; ).

Uses

Bcr-abl Inhibitor is an inhibitor of c-Abl and Bcr-abl activity. It is a COVID19-related research product.

Definition

ChEBI: 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide is a member of pyrimidines.

General Description

A cell-permeable and reverisble pyrimidine compound that binds to the c-abl myristoyl binding pocket and acts as an allosteric, non-ATP-competitive inhibitor of cellular Bcr-abl activity and Bcr-abl-dependent cellular functions. Exhibits little inhibitory effect against a panel of 63 kinases even at concentration as high as 10 μM. Exhibits potent and selective antiproliferative activity toward Bcr-abl-expressing cells (IC₅₀ = 138 nM, 194 nM, 268 nM and 273 nM in Ba/F3.p210, Ba/F3.p^185Y253H, SUP-B15 and Ba/F3.p^210E255V, and K562, respectively). Brij-35 is reported to mask the inhibitory effect of GNF-2 in cell-free c-abl and Bcr-abl kinase assays.

Biochem/physiol Actions

GNF-2 belongs to a new class of Bcr-abl inhibitors. GNF-2 appears to bind to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. It inhibits Bcr-abl phosphorylation with an IC50 of 267 nM, but does not inhibit a panel of 63 other kinases, including native c-Abl, and shows complete lack of toxicity towards cells not expressing Bcr-Abl. GNF-2 shows great potential for a new class of inhibitor to study Bcr-abl activity and to treat resistant Chronic myelogenous leukemia (CML), which is caused the Bcr-Abl oncoprotein.

GNF-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GNF-2 manufacturers

Career Henan Chemical Co

Product: GNF-2 778270-11-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

778270-11-4, GNF-2Related Search:

[Bis(trifluoroacetoxy)iodo]benzene Phosphorus oxychloride 4-(Trifluoromethoxy)phenyl isocyanate GNF5 BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)- PI-103 Selumetinib Axitinib Trametinib (+)-Camptothecin AZD5363 GNF-2

3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-2

GNF-2 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

GNF 2, >=98%

3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE

Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-

GNF-2

Bcr-abl Inhibitor

3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Bcr-abl Inhibitor - CAS 778270-11-4 - Calbiochem

CS-569

GNF2;GNF 2

GNF-2 USP/EP/BP

SARS coronavirus,GNF-2,allosteric,GNF 2,non-ATP competitive inhibitor,Ba/F3.p185Y253H,Bcr-Abl,Ba/F3.p210E255V,SARS-CoV,Ba/F3.p210,bone erosion,Inhibitor,inhibit

GNF-2, 10 mM in DMSO

778270-11-4

C18H13F3N4O2

Inhibitors