ChemicalBook > CAS DataBase List > GNF5
GNF5
- Product Name
- GNF5
- CAS No.
- 778277-15-9
- Chemical Name
- GNF5
- Synonyms
- GNF5;GNF-5;GNF 5;CS-1437;GNF 5; GNF5;GNF-5, >=98%;GNF5 USP/EP/BP;GNF-5 , 778277-15-9;GNF-5, 10 mM in DMSO;Bcr-abl Inhibitor III
- CBNumber
- CB42667791
- Molecular Formula
- C20H17F3N4O3
- Formula Weight
- 418.37
- MOL File
- 778277-15-9.mol
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GNF5 Property
- Boiling point:
- 612.4±55.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: soluble10mg/mL (clear solution)
- pka
- 13.36±0.46(Predicted)
- form
- powder
- color
- white to beige
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0511
- Product name
- GNF-5
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $133
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML0511
- Product name
- GNF-5
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $440
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 16254
- Product name
- GNF-5
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16254
- Product name
- GNF-5
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16254
- Product name
- GNF-5
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $108
- Updated
- 2024/03/01
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GNF5 Chemical Properties,Usage,Production
Uses
GNF-5 is a selective and allosteric Bcr-Abl inhibitor. It is a COVID19-related research product.
Biological Activity
GNF-5 is a BRC-Abl inhibitor.
in vivo
GNF-5 (5 mg/kg iv. or 20 mg/kg oral) has suitable pharmacokinetic parameters[1].
GNF-5 (oral, 50 or 100 mg/kg, twice daily, for 7 days) shows efficacious in vivo but can observe relapses[1].
GNF-5 (75 mg/kg, b.i.d) inhibits T315I Bcr-Abl combination with nilotinib in vivo[1].
| Animal Model: | Male Balb/c mice[1] | ||||||||||||||||
| Dosage: | 5 mg/kg, 20 mg/kg | ||||||||||||||||
| Administration: | 5 mg/kg intravenously or 20 mg/kg orally | ||||||||||||||||
| Result: |
|
| Animal Model: | p210 xenograft model[1] |
| Dosage: | 50 or 100 mg/kg |
| Administration: | oral, twice daily, for 7 days |
| Result: | Could normalize blood counts and spleen size. |
| Animal Model: | Bone marrow transduction/transplantation model[1] |
| Dosage: | 75 mg/kg |
| Administration: | twice daily |
| Result: | Showed no significant response (alone). Showed no toxicity and had a strong and sustained inhibition of Bcr-Abl-mediated signaling combination with nilotinib. |
storage
Store at +4°C
GNF5 Preparation Products And Raw materials
Raw materials
Preparation Products
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GNF5 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
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View Lastest Price from GNF5 manufacturers
Career Henan Chemical Co
- Product
- GNF5 778277-15-9
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03
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