ChemicalBook > CAS DataBase List > AC710

AC710

Product Name
AC710
CAS No.
1351522-04-7
Chemical Name
AC710
Synonyms
AC710;CS-2269;AC 710; AC-710;AC710, 10 mM in DMSO;AC710; AC 710; AC-710; N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide;5-[(1-Ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-N-[4-({[5-(2-methyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-2-pyridinecarboxamide;N-[4-[[[[5-(1,1-Dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide;2-Pyridinecarboxamide, N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-;N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
CBNumber
CB42668596
Molecular Formula
C31H42N6O4
Formula Weight
562.7
MOL File
1351522-04-7.mol
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AC710 Property

Boiling point:
580.4±50.0 °C(Predicted)
Density 
1.180±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:13.0(Max Conc. mg/mL);23.1(Max Conc. mM)
form 
A crystalline solid
pka
10.91±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29498
Product name
AC-710
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
29498
Product name
AC-710
Packaging
25mg
Price
$595
Updated
2024/03/01
Cayman Chemical
Product number
29498
Product name
AC-710
Packaging
5mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
29498
Product name
AC-710
Packaging
10mg
Price
$257
Updated
2024/03/01
Tocris
Product number
5013
Product name
AC710
Purity
≥99%(HPLC)
Packaging
10
Price
$265
Updated
2021/12/16
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AC710 Chemical Properties,Usage,Production

Uses

AC 710 is a globally selective inhibitor of platelet-derived growth factor receptor-family kinases and has been shown to have potential anti-arthritic theapeutic use.

in vivo

At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stays suppressed for an extended period after dosing is halted. No body weight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. AC710 is well tolerated at the tested doses[1].

IC 50

PDGFRα: 1.3 nM (Kd); PDGFRβ: 1 nM (Kd); c-Kit: 1 nM (Kd); FLT3: 0.6 nM (Kd); CSF1R: 1.57 nM (Kd)

storage

Store at +4°C

AC710 Preparation Products And Raw materials

Raw materials

Preparation Products

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AC710 Suppliers

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View Lastest Price from AC710 manufacturers

Career Henan Chemical Co
Product
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide 1351522-04-7
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

1351522-04-7, AC710Related Search:

AC-55541 AMG319

  • AC710
  • N-[4-[[[[5-(1,1-Dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
  • 5-[(1-Ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-N-[4-({[5-(2-methyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-2-pyridinecarboxamide
  • N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide
  • CS-2269
  • AC710; AC 710; AC-710
  • N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
  • AC 710; AC-710
  • 2-Pyridinecarboxamide, N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-
  • Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,CD117,Platelet-derived growth factor receptor,PDGFR,CD135,Inhibitor,c-Kit,AC-710,AC 710,FLT3,SCFR,inhibit,AC710
  • AC710, 10 mM in DMSO
  • 1351522-04-7