Mps1-IN-2

ChemicalBook > CAS DataBase List > Mps1-IN-2

Product Name: Mps1-IN-2
CAS No.: 1228817-38-6
Chemical Name: Mps1-IN-2
Synonyms: CS-1837;Mps1-IN-2;Msp1-IN-2;Mps1 inhibitor 2;Mps1-IN-2 >=98% (HPLC);inhibit,Inhibitor,Monopolar spindle 1,Mps1,Mps1 IN 2,Polo-like Kinase (PLK),Mps1IN2,Mps-1-IN-2;9-cyclopentyl-2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5-methyl-5H,6H,7H,8H,9H-pyrimido[4,5-b][1,4]diazepin-6-one;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one;6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Mps1-in-2
CBNumber: CB42682015
Molecular Formula: C26H36N6O3
Formula Weight: 480.6
MOL File: 1228817-38-6.mol

Less

Mps1-IN-2 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: Light brown to brown

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: M745848
Product name: Mps1-IN-2
Packaging: 5mg
Price: $150
Updated: 2021/12/16

Less

Mps1-IN-2 Chemical Properties,Usage,Production

Uses

Mps1-IN-2 is a novel Mps1 inhibitor.

Definition

ChEBI: Mps1-IN-2 is a member of piperidines.

Biological Activity

mps1-in-2 is a potent and selective atp-competitive inhibitor of mps1 kinase with the ic50 value of 145nm [1].mps1-in-2 has been reported to inhibit mps1 kinase activity with the ic50 value of 145nm, when screened at 1μm atp. in addition, mps1-in-2 has shown greater than 1000-fold selectivity to the alk and ltk enzyme. moreover, mps1-in-2 has been revealed to bound to the atp biding pocket of mpa1 and formed a hydrogen bond with the hinge backbone (glu603) at 2.74-å resolution. mps1-in-2 has been noted to abrogate sac function and override the checkpoint through direct inhibition of mps1[1].

References

[1] kwiatkowski n1, jelluma n, filippakopoulos p, soundararajan m, manak ms, kwon m, choi hg, sim t, deveraux ql, rottmann s, pellman d, shah jv, kops gj, knapp s, gray ns. small-molecule kinase inhibitors provide insight into mps1 cell cycle function. nat chem biol. 2010 may;6(5):359-68. doi: 10.1038/nchembio.345. epub 2010 apr 11.

Mps1-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Mps1-IN-2 Suppliers

China 63 The Netherlands 1 United States 9 Global 73

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7268
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1847
Advantage: 55

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5176
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9772
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Fax: 18003835034（微信）
Email: 2853979819@qq.com
Country: China
ProdList: 9718
Advantage: 58

Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2634
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8099
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6886
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 5345
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9272
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 11681
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Jiangxi Jianglan Pure Biological Reagent Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6134
Advantage: 58

Beijing Boaolong Immunology Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 5676
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6105
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Nanjing Sai Ruirui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: sales@shrbio.com
Country: CHINA
ProdList: 6871
Advantage: 58

Immunoway office

Tel: --
Fax: --
Email: jinliang.deng@immunoway.com
Country: CHINA
ProdList: 4897
Advantage: 58

Beijing Huaxia Ocean Technology Co., Ltd.

Tel: --
Fax: --
Email: huaxiabio@163.com
Country: CHINA
ProdList: 6122
Advantage: 58

Less

View Lastest Price from Mps1-IN-2 manufacturers

Career Henan Chemical Co

Product: Mps1-IN-2 1228817-38-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

1228817-38-6, Mps1-IN-2Related Search:

Mps1-IN-2

9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Mps1-in-2

CS-1837

Msp1-IN-2

Mps1 inhibitor 2

6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-

Mps1-IN-2 >=98% (HPLC)

inhibit,Inhibitor,Monopolar spindle 1,Mps1,Mps1 IN 2,Polo-like Kinase (PLK),Mps1IN2,Mps-1-IN-2

9-cyclopentyl-2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5-methyl-5H,6H,7H,8H,9H-pyrimido[4,5-b][1,4]diazepin-6-one

1228817-38-6

C26H36N6O3

Inhibitors