Mps1-IN-2

Product Name: Mps1-IN-2
CAS No.: 1228817-38-6
Chemical Name: Mps1-IN-2
Synonyms: CS-1837;Mps1-IN-2;Msp1-IN-2;Mps1 inhibitor 2;Mps1-IN-2 >=98% (HPLC);inhibit,Inhibitor,Monopolar spindle 1,Mps1,Mps1 IN 2,Polo-like Kinase (PLK),Mps1IN2,Mps-1-IN-2;9-cyclopentyl-2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5-methyl-5H,6H,7H,8H,9H-pyrimido[4,5-b][1,4]diazepin-6-one;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one;6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Mps1-in-2
CBNumber: CB42682015
Molecular Formula: C26H36N6O3
Formula Weight: 480.6
MOL File: 1228817-38-6.mol

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Mps1-IN-2 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 19401
Product name: Mps1-IN-2
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: M745848
Product name: Mps1-IN-2
Packaging: 5mg
Price: $150
Updated: 2021/12/16

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Mps1-IN-2 Chemical Properties,Usage,Production

Uses

Mps1-IN-2 is a novel Mps1 inhibitor.

Definition

ChEBI: Mps1-IN-2 is a member of piperidines.

Biological Activity

mps1-in-2 is a potent and selective atp-competitive inhibitor of mps1 kinase with the ic50 value of 145nm [1].mps1-in-2 has been reported to inhibit mps1 kinase activity with the ic50 value of 145nm, when screened at 1μm atp. in addition, mps1-in-2 has shown greater than 1000-fold selectivity to the alk and ltk enzyme. moreover, mps1-in-2 has been revealed to bound to the atp biding pocket of mpa1 and formed a hydrogen bond with the hinge backbone (glu603) at 2.74-å resolution. mps1-in-2 has been noted to abrogate sac function and override the checkpoint through direct inhibition of mps1[1].

References

[1] kwiatkowski n1, jelluma n, filippakopoulos p, soundararajan m, manak ms, kwon m, choi hg, sim t, deveraux ql, rottmann s, pellman d, shah jv, kops gj, knapp s, gray ns. small-molecule kinase inhibitors provide insight into mps1 cell cycle function. nat chem biol. 2010 may;6(5):359-68. doi: 10.1038/nchembio.345. epub 2010 apr 11.

Mps1-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Mps1-IN-2 Suppliers

China 63 The Netherlands 1 United States 9 Global 73

Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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Target molecule Corp.

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ShangHai Biochempartner Co.,Ltd

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View Lastest Price from Mps1-IN-2 manufacturers

Career Henan Chemical Co

Product: Mps1-IN-2 1228817-38-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

1228817-38-6, Mps1-IN-2Related Search:

Mps1-IN-2

9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Mps1-in-2

CS-1837

Msp1-IN-2

Mps1 inhibitor 2

6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-

Mps1-IN-2 >=98% (HPLC)

inhibit,Inhibitor,Monopolar spindle 1,Mps1,Mps1 IN 2,Polo-like Kinase (PLK),Mps1IN2,Mps-1-IN-2

9-cyclopentyl-2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5-methyl-5H,6H,7H,8H,9H-pyrimido[4,5-b][1,4]diazepin-6-one

1228817-38-6

C26H36N6O3

Inhibitors