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AHAS inhibitor

Product Name
AHAS inhibitor
CAS No.
219793-45-0
Chemical Name
AHAS inhibitor
Synonyms
CS-1880;BTB06584;AHAS inhibitor;BTB06584 >=98% (HPLC);AHAS inhibitor BTB06584;AHAS inhibitor USP/EP/BP;BTB 06584;BTB-06584;BTB06584;AHAS inhibitor LM-3254 03-11 cq;-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester;4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
CBNumber
CB42685915
Molecular Formula
C19H12ClNO6S
Formula Weight
417.82
MOL File
219793-45-0.mol
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AHAS inhibitor Property

Boiling point:
664.8±55.0 °C(Predicted)
Density 
1.466±0.06 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
<2.47 mg/mL in EtOH insoluble in; ≥17.05 mg/mL in DMSO; insoluble in H2O
form 
solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21032
Product name
BTB06584
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
21032
Product name
BTB06584
Purity
≥95%
Packaging
50mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
21032
Product name
BTB06584
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
21032
Product name
BTB06584
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
21032
Product name
BTB06584
Purity
≥98%
Packaging
25mg
Price
$199
Updated
2024/03/01
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AHAS inhibitor Chemical Properties,Usage,Production

Uses

BTB06584 is F1 Fo-ATPase inhibitor. It can be used in biological study of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis.

Biological Activity

ischaemia compromises mitochondrial respiration. consequently, the mitochondrial 1fo-atp synthase reverses and plays as a proton-pumping atpase, so maintaining the mitochondrial membrane potential (δψm), while accelerating atp depletion and cell death. btb06584 is an if1-dependent selective inhibitor of the mitochondrial f1fo-atpase.

in vitro

btb inhibited f1fo-atpase activity with no effect on the mitochondrial membrane potential (δψm) or o2 consumption. atp consumption decreased via inhibition of respiration, and ischaemic cell death was reduced. btb efficiency increased by if1 overexpression and reduced by silencing this protein. in addition, btb rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the atpif1a gene is lost [1].

in vivo

the btb-mediated protection was further tested in neurons. primary cultured cortical neurons of mice were exposed to ogd, treated or not with btb, followed by rx. the resulting cell death was significantly reduced by btb, as scored by pi staining, compared with cells left untreated during ogd [1].

References

[1] ivanes f, faccenda d, gatliff j, ahmed aa, cocco s, cheng ch, allan e, russell c, duchen mr, campanella m. the compound btb06584 is an if1-dependent selective inhibitor of the mitochondrial f1 fo-atpase. br j pharmacol. 2014;171(18):4193-206.

AHAS inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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AHAS inhibitor Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
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2922
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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61
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
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Shanghai Qinghang Chemical Co. Ltd.
Tel
021-50840321, 18601625411
Fax
021-50840321
Email
thomasleehz@hotmail.com
Country
China
ProdList
216
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
Fax
025-68650336
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Hubei Jusheng Technology Co.,Ltd
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027-59599241 18871490274
Fax
027-59599241
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1400878000@qq.com
Country
China
ProdList
9958
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58
LETOPHARM LIMITED
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+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
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58

219793-45-0, AHAS inhibitorRelated Search:


  • AHAS inhibitor
  • BTB06584
  • -Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
  • CS-1880
  • BTB 06584;BTB-06584;BTB06584
  • 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
  • 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester AHAS inhibitor BTB06584
  • AHAS inhibitor 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
  • AHAS inhibitor BTB06584
  • AHAS inhibitor LM-3254 03-11 cq
  • Benzoic acid, 4-chloro-, 2-nitro-5-(phenylsulfonyl)phenyl ester
  • BTB06584 >=98% (HPLC)
  • AHAS inhibitor USP/EP/BP
  • IF1,mitochondrial,cardioprotective,ATP Synthase,ATPsynthase,ischaemic,BTB-06584,BTB 06584,BTB06584,inhibit,Inhibitor
  • 219793-45-0
  • C19H12ClNO6S
  • Inhibitors