AHAS inhibitor

Product Name: AHAS inhibitor
CAS No.: 219793-45-0
Chemical Name: AHAS inhibitor
Synonyms: CS-1880;BTB06584;AHAS inhibitor;BTB06584 >=98% (HPLC);AHAS inhibitor BTB06584;AHAS inhibitor USP/EP/BP;BTB 06584;BTB-06584;BTB06584;AHAS inhibitor LM-3254 03-11 cq;-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester;4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester
CBNumber: CB42685915
Molecular Formula: C19H12ClNO6S
Formula Weight: 417.82
MOL File: 219793-45-0.mol

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AHAS inhibitor Property

Boiling point:: 664.8±55.0 °C(Predicted)
Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: <2.47 mg/mL in EtOH insoluble in; ≥17.05 mg/mL in DMSO; insoluble in H2O
form: solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21032
Product name: BTB06584
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21032
Product name: BTB06584
Purity: ≥95%
Packaging: 50mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 21032
Product name: BTB06584
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 21032
Product name: BTB06584
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 21032
Product name: BTB06584
Purity: ≥98%
Packaging: 25mg
Price: $199
Updated: 2024/03/01

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AHAS inhibitor Chemical Properties,Usage,Production

Uses

BTB06584 is F1 Fo-ATPase inhibitor. It can be used in biological study of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis.

Biological Activity

ischaemia compromises mitochondrial respiration. consequently, the mitochondrial 1fo-atp synthase reverses and plays as a proton-pumping atpase, so maintaining the mitochondrial membrane potential (δψm), while accelerating atp depletion and cell death. btb06584 is an if1-dependent selective inhibitor of the mitochondrial f1fo-atpase.

in vitro

btb inhibited f1fo-atpase activity with no effect on the mitochondrial membrane potential (δψm) or o2 consumption. atp consumption decreased via inhibition of respiration, and ischaemic cell death was reduced. btb efficiency increased by if1 overexpression and reduced by silencing this protein. in addition, btb rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the atpif1a gene is lost [1].

in vivo

the btb-mediated protection was further tested in neurons. primary cultured cortical neurons of mice were exposed to ogd, treated or not with btb, followed by rx. the resulting cell death was significantly reduced by btb, as scored by pi staining, compared with cells left untreated during ogd [1].

References

[1] ivanes f, faccenda d, gatliff j, ahmed aa, cocco s, cheng ch, allan e, russell c, duchen mr, campanella m. the compound btb06584 is an if1-dependent selective inhibitor of the mitochondrial f1 fo-atpase. br j pharmacol. 2014;171(18):4193-206.

AHAS inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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AHAS inhibitor Suppliers

China 57 France 1 United States 13 Global 71

MedChemexpress LLC

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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Aladdin Scientific

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ApexBio Technology

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Cayman Chemical Company

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MedChemExpress

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219793-45-0, AHAS inhibitorRelated Search:

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AHAS inhibitor

BTB06584

-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester

CS-1880

BTB 06584;BTB-06584;BTB06584

4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester

4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester AHAS inhibitor BTB06584

AHAS inhibitor 4-Chlorobenzoic acid 2-nitro-5-(phenylsulfonyl)phenyl ester

AHAS inhibitor BTB06584

AHAS inhibitor LM-3254 03-11 cq

Benzoic acid, 4-chloro-, 2-nitro-5-(phenylsulfonyl)phenyl ester

BTB06584 >=98% (HPLC)

AHAS inhibitor USP/EP/BP

IF1,mitochondrial,cardioprotective,ATP Synthase,ATPsynthase,ischaemic,BTB-06584,BTB 06584,BTB06584,inhibit,Inhibitor

219793-45-0

C19H12ClNO6S

Inhibitors