4-Bromo-2-(difluoromethyl)pyridine

Product Name: 4-Bromo-2-(difluoromethyl)pyridine
CAS No.: 1211580-54-9
Chemical Name: 4-Bromo-2-(difluoromethyl)pyridine
Synonyms: 4-Bromo-2-(difL;4-Bromo-2-(difluoromethyl)pyridine;Pyridine, 4-bromo-2-(difluoromethyl)-;4-Bromo-2-(difluoromethyl)pyridine 97%;4-Bromo-alpha,alpha-difluoro-2-picoline
CBNumber: CB42688471
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: 1211580-54-9.mol

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4-Bromo-2-(difluoromethyl)pyridine Property

Boiling point:: 210.3±35.0 °C(Predicted)
Density: 1.640±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.27±0.10(Predicted)
form: liquid
color: Colourless to light yellow
InChI: InChI=1S/C6H4BrF2N/c7-4-1-2-10-5(3-4)6(8)9/h1-3,6H
InChIKey: MNMLGZMORMDPJI-UHFFFAOYSA-N
SMILES: C1(C(F)F)=NC=CC(Br)=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B997813
Product name: 4-Bromo-2-(difluoromethyl)pyridine
Packaging: 50mg
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: PC51201
Product name: 4-Bromo-2-(difluoromethyl)pyridine
Purity: 97%
Packaging: 100mg
Price: $66
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-D7
Product name: 4-Bromo-2-(difluoromethyl)pyridine
Packaging: 100mg
Price: $72
Updated: 2021/12/16

Apolloscientific

Product number: PC51201
Product name: 4-Bromo-2-(difluoromethyl)pyridine
Purity: 97%
Packaging: 500mg
Price: $143
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-D7
Product name: 4-Bromo-2-(difluoromethyl)pyridine
Packaging: 500mg
Price: $157
Updated: 2021/12/16

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4-Bromo-2-(difluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

131747-63-2

1211580-54-9

Step 1: Synthesis of 4-bromo-2-(difluoromethyl)pyridine: To 4-bromopyridine-2-carbaldehyde (5.0 g, 26.88 mmol) was added diethylamino sulfur trifluoride (7.03 mL, 53.7 mmol) at room temperature and the reaction mixture was stirred for 16 hours. Upon completion of the reaction, the reaction was quenched with aqueous sodium bicarbonate (50 mL) and subsequently extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with brine (2 x 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography (100-200 mesh) using a hexane solution of 5% ethyl acetate as eluent afforded 4-bromo-2-(difluoromethyl)pyridine (3.0 g, 14.492 mmol, 54% yield).1H NMR (400 MHz, CDCl3) δ= 8.48 (d, J = 4.9 Hz, 1H), 7.82 (d, J = 1.5 Hz, 1H), 7.66-7.50 (m, 1H), 6.60 (t, 1H).LCMS: 207.9 [M + H]+.

References

[1] Patent: WO2016/161160, 2016, A1. Location in patent: Paragraph 0207
[2] Patent: US2015/152108, 2015, A1. Location in patent: Paragraph 0480; 0481
[3] Patent: WO2016/79709, 2016, A1. Location in patent: Page/Page column 179
[4] Patent: US2010/125082, 2010, A1. Location in patent: Page/Page column 24; 25
[5] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 78

4-Bromo-2-(difluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-(difluoromethyl)pyridine Suppliers

China 78 India 1 United Kingdom 1 United States 6 Global 86

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View Lastest Price from 4-Bromo-2-(difluoromethyl)pyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-2-(difluoromethyl)pyridine 1211580-54-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-07

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-bromo-2-(difluoromethyl)pyridine 1211580-54-9
Price: US $3.00-9.00/KG
Min. Order: 0.01KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

1211580-54-9, 4-Bromo-2-(difluoromethyl)pyridineRelated Search:

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1211580-54-9

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