Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- Product Name
- Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- CAS No.
- 878650-31-8
- Chemical Name
- Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- Synonyms
- Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate;4-Pyrimidinecarboxylic acid, 2,6-dichloro-5-methoxy-, methyl ester
- CBNumber
- CB42693257
- Molecular Formula
- C7H6Cl2N2O3
- Formula Weight
- 237.04
- MOL File
- 878650-31-8.mol
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3999AC
- Product name
- Methyl2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 3999AC
- Product name
- Methyl2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- Packaging
- 250mg
- Price
- $259
- Updated
- 2021/12/16
- Product number
- 096040
- Product name
- Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- HCH0369121
- Product name
- METHYL-2,6-DICHLORO-5-METHOXYPYRIMIDINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.59
- Updated
- 2021/12/16
- Product number
- 096040
- Product name
- Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $924
- Updated
- 2021/12/16
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate Chemical Properties,Usage,Production
Synthesis
67-56-1
1446253-05-9
878650-31-8
Example 5 Preparation of methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate: 2,6-dichloro-5-methoxypyrimidine-4-carboxaldehyde (50 g, 0.24 mol) was dissolved in a solvent mixture of methanol (1 L) and water (60 mL). Sodium bicarbonate (400 g) was added to this solution. A methanol/water (600 mL, v/v=9:1) solution of 2M bromine (192 g, 1.2 mol) was slowly added dropwise to the pyrimidine solution over a period of 45 min at 0°C while maintaining stirring. After the dropwise addition was completed, stirring was continued at the same temperature for 1 hour. Subsequently, the reaction mixture was warmed to room temperature and stirred for 4 hours. Upon completion of the reaction, the mixture was slowly poured into a mixture containing crushed ice (2 L), sodium bisulfite (50 g) and sodium chloride (200 g). The product was extracted with ethyl acetate (1L x 2), the organic layers were combined and dried over anhydrous sodium sulfate and filtered. The solvent was removed by concentration under reduced pressure to give a viscous mass, which was left to cure to give methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate (50.8 g, 87% yield): ESIMS m/z 238 ([M+H]+).
References
[1] Patent: US2014/274703, 2014, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: US2014/274701, 2014, A1. Location in patent: Paragraph 0156; 0157
[3] Patent: US2014/274696, 2014, A1. Location in patent: Paragraph 0238; 0239
[4] Patent: WO2013/102111, 2013, A1. Location in patent: Page/Page column 23
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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