ChemicalBook > CAS DataBase List > GSK2141795

GSK2141795

Product Name: GSK2141795
CAS No.: 1047634-65-0
Chemical Name: GSK2141795
Synonyms: GSK795;CS-1304;Uprosertib;GSK2141795;GSK 2141795C;Uprosertib(GSK2141795);Uprosertib , GSK2141795C;Uprosertib, 10 mM in DMSO;GSK2141795 (Uprosertib, GSK795);Uprosertib (GSK-2141795,GSK795)
CBNumber: CB42705086
Molecular Formula: C18H16Cl2F2N4O2
Formula Weight: 429.25
MOL File: 1047634-65-0.mol

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GSK2141795 Property

storage temp.: Store at -20°C
solubility: DMSO:45.33(Max Conc. mg/mL);105.6(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.33(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);198.02(Max Conc. mM)
form: Powder
color: White to off-white
InChI: InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
InChIKey: AXTAPYRUEKNRBA-JTQLQIEISA-N
SMILES: O1C(Cl)=C(C2N(C)N=CC=2Cl)C=C1C(N[C@@H](CC1=CC=C(F)C(F)=C1)CN)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19904
Product name: Uprosertib
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19904
Product name: Uprosertib
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19904
Product name: Uprosertib
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 19904
Product name: Uprosertib
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: G797425
Product name: Uprosertib
Packaging: 1mg
Price: $60
Updated: 2021/12/16

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GSK2141795 Chemical Properties,Usage,Production

Uses

Uprosertib is a potent and selective inhibitor of pan-Akt (1). Serine/threonine protein kinases, such as Akt, play important roles in cellular activities including cell survival and apoptosis.

IC 50

Akt3: 38 nM (IC₅₀); Akt1: 180 nM (IC₅₀); Akt2: 328 nM (IC₅₀); ROCK1: 1570 nM (IC₅₀); ROCK2: 1850 nM (IC₅₀); CDK7: 2100 nM (IC₅₀)

GSK2141795 Preparation Products And Raw materials

Raw materials

Preparation Products

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1047634-65-0, GSK2141795Related Search:

ZM 39923 HCl RGB-286638 (free base) SR9009 Fexaramine TD52 BAM15 (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide TG4-155 PH 797804 NVP-TAE684

GSK2141795

Uprosertib

Uprosertib(GSK2141795)

Uprosertib , GSK2141795C

GSK 2141795C

N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide

Uprosertib, 98%, a potent and selective pan-Akt inhibitor

CS-1304

Uprosertib (GSK-2141795,GSK795)

GSK2141795 (Uprosertib, GSK795)

GSK795

2-Furancarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-

GSK-2141795,GSK 2141795,Uprosertib,inhibit,Akt,Inhibitor,PKB,Protein kinase B

(S)-N-(1-Amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide

Uprosertib, 10 mM in DMSO

1047634-65-0

C18H16Cl2F2N4O2

API