ChemicalBook > CAS DataBase List > 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
- Product Name
- 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
- CAS No.
- 953769-46-5
- Chemical Name
- 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
- Synonyms
- BLZ945;106245;CS-1735;4-((2-(((1R;Sotuletinib;BLZ-945 >=95%;BLZ-945;BLZ 945;Sotuletinib (BLZ945);BLZ945 (Sotuletinib);Sotuletinib, 10 mM in DMSO
- CBNumber
- CB42706230
- Molecular Formula
- C20H22N4O3S
- Formula Weight
- 398.48
- MOL File
- 953769-46-5.mol
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4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Property
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥19.9 mg/mL in DMSO
- form
- solid
- pka
- 13.92±0.46(Predicted)
- color
- Pale yellow
- InChIKey
- ADZBMFGQQWPHMJ-RHSMWYFYSA-N
- SMILES
- C1(C(NC)=O)=NC=CC(OC2C=C3SC(N[C@@H]4CCCC[C@H]4O)=NC3=CC=2)=C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19626
- Product name
- BLZ-945
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19626
- Product name
- BLZ-945
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $407
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19626
- Product name
- BLZ-945
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $648
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19626
- Product name
- BLZ-945
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $2159
- Updated
- 2024/03/01
TRC
- Product number
- B595835
- Product name
- BLZ945
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
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4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Chemical Properties,Usage,Production
Uses
BLZ945 is a tumor-associated macrophage targeting the treatment of glioblastoma multiforme, a most common type of aggresive brain cancer.
in vivo
Mice are treated with Sotuletinib or vehicle, and evaluated for symptom-free survival. Median survival in the vehicle-treated cohort is 5.7 weeks. In striking contrast, Sotuletinib significantly improves long-term survival. This endpoint is chosen because Ink4a/Arf / mice develop spontaneous tumors, including lymphomas and sarcomas, beginning at ~30 weeks. Sotuletinib is well-tolerated over long-term treatment, with no visible side-effects, consistent with histopathological studies. Histological grading revealed high-grade, invasive gliomas in all vehicle-treated mice. By contrast, Sotuletinib-treated animals have significantly less-malignant tumors, and no detectable lesions in 55.6% of asymptomatic mice at the endpoint[1]. Mice receiving Sotuletinib shows reduced CSF1R staining in both cervical tumors and the associated stroma, with a significant decrease in CSF1R+ stromal macrophages relative to vehicle-treated mice (P<0.05)[2].
storage
+4°C
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide manufacturers
Career Henan Chemical Co
- Product
- 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide 953769-46-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23