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Optovin

Product Name
Optovin
CAS No.
348575-88-2
Chemical Name
Optovin
Synonyms
CS-1131;Optovin;Oprovin;Optovin, 10 mM in DMSO;Optovin (mixture of isomers);Optovin, photoactive TRPA1 activator;Photochromic TrpA1 Channel Activator, Optovin;5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone;5-((2,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one;4-Thiazolidinone, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-
CBNumber
CB42708133
Molecular Formula
C15H13N3OS2
Formula Weight
315.41
MOL File
348575-88-2.mol
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Optovin Property

Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO (up to 30 mg/ml)
pka
7.65±0.50(Predicted)
form 
solid
color 
Tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05206
Product name
Photochromic TrpA1 Channel Activator, Optovin
Packaging
10 mg
Price
$195
Updated
2025/07/31
Cayman Chemical
Product number
14851
Product name
Optovin
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
14851
Product name
Optovin
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
14851
Product name
Optovin
Purity
≥98%
Packaging
25mg
Price
$317
Updated
2024/03/01
Cayman Chemical
Product number
14851
Product name
Optovin
Purity
≥98%
Packaging
50mg
Price
$553
Updated
2024/03/01
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Optovin Chemical Properties,Usage,Production

Description

Optovin (348575-88-2) is a reversible photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50?= 2 μM) and mice,?in vivo. Photodetection is performed by sensory neurons expressing the TRPA1 cation channel which is activated via structure-dependent photochemical reactions with redox-sensitive cysteine residues.1

Uses

Optovin activates human TRPA1 via structure-dependent photochemistry.

Definition

ChEBI: Optovin is a member of the class of thiazolidinone that is rhodanine in which the two methylene hydrogens have been replaced by a 2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene group. A TRPA1 ligand that can be reversibly photoactivated. It has a role as a TRPA1 channel agonist. It is a member of pyrroles, a member of pyridines, an olefinic compound and a thiazolidinone. It is functionally related to a rhodanine.

in vivo

Optovin (1-10 μM) causes light-dependent motor excitation in vivo[1].
Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice[1].
Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish[1].

storage

Store at +4°C

References

[1] DAVID KOKEL. Photochemical activation of TRPA1 channels in neurons and animals[J]. Nature chemical biology, 2013, 9 4: 257-263. DOI:10.1038/nchembio.1183

Optovin Preparation Products And Raw materials

Raw materials

Preparation Products

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Optovin Suppliers

China 82 India 1 The Netherlands 1 United Kingdom 1 United States 13 Global 98
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Optovin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Optovin 348575-88-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Optovin 348575-88-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
4-?Thiazolidinone, 5-?[[2,?5-?dimethyl-?1-?(3-?pyridinyl)?-?1H-?pyrrol-?3-?yl]?methylene]?-?2-?thioxo- 348575-88-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

348575-88-2, OptovinRelated Search:

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  • Optovin
  • CS-1131
  • 4-Thiazolidinone, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-
  • 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone
  • Oprovin
  • 5-((2,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one
  • Optovin (mixture of isomers)
  • Optovin, photoactive TRPA1 activator
  • Optovin, 10 mM in DMSO
  • Photochromic TrpA1 Channel Activator, Optovin
  • 348575-88-2
  • Inhibitors