ChemicalBook > CAS DataBase List > MGL-3196

MGL-3196

Product Name
MGL-3196
CAS No.
920509-32-6
Chemical Name
MGL-3196
Synonyms
Resmetirom;CS-2429;VIA3196;MGL-3196;VIA-3196;Resmetirom(MGL-3196);MGL-3196(Resmetirom);Resmetirom, 10 mM in DMSO;Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196
CBNumber
CB42714673
Molecular Formula
C17H12Cl2N6O4
Formula Weight
435.22
MOL File
920509-32-6.mol
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MGL-3196 Property

Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM)
form 
A crystalline solid
pka
3.96±0.40(Predicted)
color 
Yellow to orange
InChI
InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)
InChIKey
FDBYIYFVSAHJLY-UHFFFAOYSA-N
SMILES
N1=C(C#N)C(=O)NC(=O)N1C1=CC(Cl)=C(OC2=NNC(=O)C(C(C)C)=C2)C(Cl)=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23845
Product name
MGL-3196
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23845
Product name
MGL-3196
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
23845
Product name
MGL-3196
Purity
≥98%
Packaging
10mg
Price
$341
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0018402
Product name
MGL-3196
Purity
95.00%
Packaging
5MG
Price
$505.57
Updated
2021/12/16
DC Chemicals
Product number
DC9995
Product name
MGL-3196(Resmetirom)
Purity
>98%
Packaging
100mg
Price
$600
Updated
2021/12/16
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MGL-3196 Chemical Properties,Usage,Production

Description

MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.

Uses

Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-beta agonist. It works by blocking the formation of fat in the liver and can be used to treat non-alcoholic steatohepatitis (NASH).

MGL-3196 Preparation Products And Raw materials

Raw materials

Preparation Products

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MGL-3196 Suppliers

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View Lastest Price from MGL-3196 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Resmetirom 920509-32-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-23
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Resmetirom. 920509-32-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2025-01-07
Chengdu Aupone Pharmaceutical Co.Ltd.
Product
Resmetirom 920509-32-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99
Supply Ability
3 TONS
Release date
2024-08-30

920509-32-6, MGL-3196Related Search:


  • Resmetirom (MGL-3196,VIA-3196)
  • MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196
  • VIA3196
  • VIA-3196
  • MGL-3196
  • Resmetirom
  • 2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile
  • CS-2429
  • 1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-
  • 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
  • Resmetirom(MGL-3196)
  • MGL-3196(Resmetirom)
  • Resmetirom, 10 mM in DMSO
  • 920509-32-6
  • C17H12Cl2N6O4
  • API