MGL-3196

ChemicalBook > CAS DataBase List > MGL-3196

Product Name: MGL-3196
CAS No.: 920509-32-6
Chemical Name: MGL-3196
Synonyms: Resmetirom;CS-2429;VIA3196;MGL-3196;VIA-3196;Resmetirom(MGL-3196);MGL-3196(Resmetirom);Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CBNumber: CB42714673
Molecular Formula: C17H12Cl2N6O4
Formula Weight: 435.22
MOL File: 920509-32-6.mol

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MGL-3196 Property

Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM)
form: A crystalline solid
pka: 3.96±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23845
Product name: MGL-3196
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23845
Product name: MGL-3196
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 23845
Product name: MGL-3196
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0018402
Product name: MGL-3196
Purity: 95.00%
Packaging: 5MG
Price: $505.57
Updated: 2021/12/16

DC Chemicals

Product number: DC9995
Product name: MGL-3196(Resmetirom)
Purity: >98%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

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MGL-3196 Chemical Properties,Usage,Production

Description

MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC₅₀s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC₅₀ = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.

MGL-3196 Preparation Products And Raw materials

Raw materials

Preparation Products

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920509-32-6, MGL-3196Related Search:

Resmetirom (MGL-3196,VIA-3196)

MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196

VIA3196

VIA-3196

MGL-3196

Resmetirom

2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile

CS-2429

1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Resmetirom(MGL-3196)

MGL-3196(Resmetirom)

920509-32-6

C17H12Cl2N6O4

API