MGL-3196
- Product Name
- MGL-3196
- CAS No.
- 920509-32-6
- Chemical Name
- MGL-3196
- Synonyms
- Resmetirom;CS-2429;VIA3196;MGL-3196;VIA-3196;Resmetirom(MGL-3196);MGL-3196(Resmetirom);Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
- CBNumber
- CB42714673
- Molecular Formula
- C17H12Cl2N6O4
- Formula Weight
- 435.22
- MOL File
- 920509-32-6.mol
MGL-3196 Property
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM)
- form
- A crystalline solid
- pka
- 3.96±0.40(Predicted)
- color
- Yellow to orange
- InChI
- InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)
- InChIKey
- FDBYIYFVSAHJLY-UHFFFAOYSA-N
- SMILES
- N1=C(C#N)C(=O)NC(=O)N1C1=CC(Cl)=C(OC2=NNC(=O)C(C(C)C)=C2)C(Cl)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23845
- Product name
- MGL-3196
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 23845
- Product name
- MGL-3196
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 23845
- Product name
- MGL-3196
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- API0018402
- Product name
- MGL-3196
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.57
- Updated
- 2021/12/16
- Product number
- DC9995
- Product name
- MGL-3196(Resmetirom)
- Purity
- >98%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
MGL-3196 Chemical Properties,Usage,Production
Description
MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.
Uses
Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-beta agonist. It works by blocking the formation of fat in the liver and can be used to treat non-alcoholic steatohepatitis (NASH).
MGL-3196 Preparation Products And Raw materials
Raw materials
Preparation Products
MGL-3196 Suppliers
View Lastest Price from MGL-3196 manufacturers
- Product
- Resmetirom 920509-32-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-07-23
- Product
- Resmetirom 920509-32-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 3 TONS
- Release date
- 2024-08-30