4-Chloro-5-(trifluoromethyl)quinazoline
- Product Name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- CAS No.
- 16499-63-1
- Chemical Name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- Synonyms
- 4-Chloro-5-(trifluoromethyl)quinazoline;Quinazoline, 4-chloro-5-(trifluoromethyl)-;4-chloro-5-(trifluoroMethyl)-3,4-dihydroquinazoline
- CBNumber
- CB42717629
- Molecular Formula
- C9H4ClF3N2
- Formula Weight
- 232.59
- MOL File
- 16499-63-1.mol
4-Chloro-5-(trifluoromethyl)quinazoline Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 161790
- Product name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- Purity
- 95%
- Packaging
- 2.500g
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CM142727
- Product name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $1683
- Updated
- 2021/12/16
- Product number
- CD11241447
- Product name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $2079
- Updated
- 2021/12/16
- Product number
- 16499631
- Product name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- Packaging
- 10g
- Price
- $3651.5
- Updated
- 2021/12/16
- Product number
- 16499631
- Product name
- 4-Chloro-5-(trifluoromethyl)quinazoline
- Packaging
- 25g
- Price
- $5360
- Updated
- 2021/12/16
4-Chloro-5-(trifluoromethyl)quinazoline Chemical Properties,Usage,Production
Synthesis
436-73-7
16499-63-1
The general procedure for the synthesis of 4-chloro-5-(trifluoromethyl)quinazolin-4(3H)-one from 5-(trifluoromethyl)quinazolin-4(3H)-one was as follows: triethylamine (29.3 ml, 210 mmol) was slowly added to a mixture of phosphoryl chloride (331 g, 2.16 mol) containing intermediate 14-b (8.00 g, 37.4 mmol) at 0 °C. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was dissolved in ethyl acetate (200 ml) and the solution was quenched by slowly pouring it into ice (200 g). After separation of the organic layer, it was washed sequentially with water (1 x 100 ml), 10% aqueous sodium bicarbonate solution (2 x 100 ml), water (1 x 100 ml) and brine (1 x 100 ml). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (ratio tapered from 1/0 to 1/1) to afford the target product Intermediate 14 (7.97 g, 91.38% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δppm of 7.89-8.06 (m, 1H), 8.22 (d, J=7.50 Hz, 1H), 8.31 (d, J=8.38 Hz, 1H), 9.11 (s, 1H).
References
[1] Patent: WO2016/91791, 2016, A1. Location in patent: Page/Page column 26; 27
[2] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 84
4-Chloro-5-(trifluoromethyl)quinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-5-(trifluoromethyl)quinazoline Suppliers
- Tel
- --
- Fax
- --
- info@synthonix.com
- Country
- United States
- ProdList
- 6872
- Advantage
- 58
- Tel
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- Fax
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- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80
View Lastest Price from 4-Chloro-5-(trifluoromethyl)quinazoline manufacturers
- Product
- 4-Chloro-5-(trifluoromethyl)quinazoline 16499-63-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12