N-succiniMidyl 4-(2-pyridyldithio)pentanoate

Product Name: N-succiniMidyl 4-(2-pyridyldithio)pentanoate
CAS No.: 341498-08-6
Chemical Name: N-succiniMidyl 4-(2-pyridyldithio)pentanoate
Synonyms: N-succiniMidyl 4-(2-pyridyldithio)pentanoate;N-succinimidyl 4-(2-pyridyldithio)-pentanoate / SPP;2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)pentanoate;2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfaneyl)pentanoate;4-(Pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester;Pentanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB42730828
Molecular Formula: C14H16N2O4S2
Formula Weight: 340.41784
MOL File: 341498-08-6.mol

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N-succiniMidyl 4-(2-pyridyldithio)pentanoate Property

Melting point:: 48-49 °C
Boiling point:: 483.5±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
pka: 1.83±0.19(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0102531
Product name: SPP
Packaging: 100mg
Price: $460
Updated: 2021/12/16

AK Scientific

Product number: 7303AJ
Product name: N-Succinimidyl4-(2-pyridyldithio)pentanoate
Packaging: 250mg
Price: $1544
Updated: 2021/12/16

ChemScene

Product number: CS-0102531
Product name: SPP
Packaging: 1g
Price: $2299
Updated: 2021/12/16

SynChem

Product number: SC-27109
Product name: 4-(Pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester
Purity: 90+%
Packaging: 1g
Price: $3150
Updated: 2021/12/16

Absolute Chiral

Product number: A2001-00-M
Product name: 2,5-dioxopyrrolidin-1-yl4-(pyridin-2-yldisulfanyl)pentanoate
Purity: techgrade
Packaging: 50mg
Price: $198
Updated: 2021/12/16

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N-succiniMidyl 4-(2-pyridyldithio)pentanoate Chemical Properties,Usage,Production

Uses

SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].

IC 50

Cleavable Linker; Disulfide Cleavable Linker

References

[1] Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. DOI:10.1021/mp5007757

N-succiniMidyl 4-(2-pyridyldithio)pentanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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N-succiniMidyl 4-(2-pyridyldithio)pentanoate Suppliers

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341498-08-6, N-succiniMidyl 4-(2-pyridyldithio)pentanoateRelated Search:

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4-(Pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester

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2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfaneyl)pentanoate

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Pentanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester

341498-08-6