ChemicalBook > CAS DataBase List > LCH-7749944
LCH-7749944
- Product Name
- LCH-7749944
- CAS No.
- 796888-12-5
- Chemical Name
- LCH-7749944
- Synonyms
- GNF-PF-2356;LCH-7749944;LCH-7749944 ，S1976;LCH-7749944， GNF-PF-2356;LCH-7749944, 10 mM in DMSO;N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-;proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944
- CBNumber
- CB42731092
- Molecular Formula
- C20H22N4O2
- Formula Weight
- 350.41
- MOL File
- 796888-12-5.mol
More
Less
LCH-7749944 Property
- Boiling point:
- 580.0±58.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO: 250 mg/mL (713.45 mM)
- pka
- 7.68±0.30(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0088726
- Product name
- LCH-7749944
- Purity
- 99.43%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0088726
- Product name
- LCH-7749944
- Purity
- 99.43%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0088726
- Product name
- LCH-7749944
- Purity
- 99.43%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0088726
- Product name
- LCH-7749944
- Purity
- 99.43%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN25301
- Product name
- LCH7749944
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
More
Less
LCH-7749944 Chemical Properties,Usage,Production
Uses
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
IC 50
PAK4: 14.93 μM (IC50)
References
[1] Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32. DOI:10.1016/j.canlet.2011.11.007
LCH-7749944 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
LCH-7749944 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58